Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 773244..773997 | Replicon | chromosome |
| Accession | NZ_CP056852 | ||
| Organism | Citrobacter freundii strain RHBSTW-00119 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | R8WN26 |
| Locus tag | HV078_RS03720 | Protein ID | WP_016154457.1 |
| Coordinates | 773244..773621 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HV078_RS03725 | Protein ID | WP_162838704.1 |
| Coordinates | 773671..773997 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV078_RS03695 | 769388..771247 | + | 1860 | WP_032950101.1 | bifunctional glutathionylspermidine amidase/synthase | - |
| HV078_RS03700 | 771286..771585 | - | 300 | WP_032950098.1 | hypothetical protein | - |
| HV078_RS03705 | 771597..772442 | - | 846 | Protein_726 | DUF4942 domain-containing protein | - |
| HV078_RS03710 | 772523..772726 | - | 204 | WP_009652505.1 | DUF957 domain-containing protein | - |
| HV078_RS03715 | 772756..773247 | - | 492 | WP_009652438.1 | hypothetical protein | - |
| HV078_RS03720 | 773244..773621 | - | 378 | WP_016154457.1 | TA system toxin CbtA family protein | Toxin |
| HV078_RS03725 | 773671..773997 | - | 327 | WP_162838704.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HV078_RS03730 | 774054..774275 | - | 222 | WP_009652392.1 | DUF987 domain-containing protein | - |
| HV078_RS03735 | 774289..774771 | - | 483 | WP_016154455.1 | DNA repair protein RadC | - |
| HV078_RS03740 | 774783..775001 | - | 219 | WP_009652503.1 | hypothetical protein | - |
| HV078_RS03745 | 775012..775473 | - | 462 | WP_045890390.1 | antirestriction protein | - |
| HV078_RS03750 | 775502..775756 | - | 255 | WP_009652519.1 | hypothetical protein | - |
| HV078_RS03755 | 775756..776574 | - | 819 | WP_009652424.1 | DUF945 domain-containing protein | - |
| HV078_RS03760 | 776678..776911 | - | 234 | WP_009652474.1 | DUF905 domain-containing protein | - |
| HV078_RS03765 | 776967..777188 | - | 222 | WP_032950095.1 | hypothetical protein | - |
| HV078_RS03770 | 777270..777782 | - | 513 | WP_032950094.1 | DUF4234 domain-containing protein | - |
| HV078_RS03775 | 777831..778301 | - | 471 | WP_009652431.1 | hypothetical protein | - |
| HV078_RS03780 | 778348..778659 | - | 312 | WP_009652410.1 | hypothetical protein | - |
| HV078_RS03785 | 778672..778938 | - | 267 | WP_032950091.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 9.5224
>T164331 WP_016154457.1 NZ_CP056852:c773621-773244 [Citrobacter freundii]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
Download Length: 378 bp
>T164331 NZ_CP072897:1595396-1595710 [Bartonella henselae]
ATGATACATAAAAGAACGAATGAAGGTGACTTGGTAATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAATCCACCTAAAGGTTTTCCCACAACTCTCGTGCGTATAGTCCAACGAAAATTATTTATGCTGGATAAAGCAGTTGATC
TCAAAGATTTACGCAGTCCTCCGGGTAATCGTTTAGATGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGCATTTGTTTTGAGTGGCGTTCTAATGGTGCCTATGAAGTTGAAATCATCGATTATCATTGA
ATGATACATAAAAGAACGAATGAAGGTGACTTGGTAATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAATCCACCTAAAGGTTTTCCCACAACTCTCGTGCGTATAGTCCAACGAAAATTATTTATGCTGGATAAAGCAGTTGATC
TCAAAGATTTACGCAGTCCTCCGGGTAATCGTTTAGATGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGCATTTGTTTTGAGTGGCGTTCTAATGGTGCCTATGAAGTTGAAATCATCGATTATCATTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12079.85 Da Isoelectric Point: 6.6283
>AT164331 WP_162838704.1 NZ_CP056852:c773997-773671 [Citrobacter freundii]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
Download Length: 327 bp
>AT164331 NZ_CP072897:1595727-1596023 [Bartonella henselae]
ATGAAAAATTATATTGCTATTCATCCCGGAGAAATTTTACGGGAAGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
TCTTGCCAAAGCCTTGAATGTTCCACGCACTCGGATAGAACGTATTGTAGCAGAAAATAGTCCGGTAACTCCTGATACAG
CACTACGATTAGCCTATTTTTTTGATACAACAGCTGAATTCTGGCTTAACATGCAAGCTGCTTACGACGTTAGTGTCTTA
CAAGCTGAAAAAGCAGATGAATTTTCCAAAATTAGTAAATTTGAATGTAGGGTTTAA
ATGAAAAATTATATTGCTATTCATCCCGGAGAAATTTTACGGGAAGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
TCTTGCCAAAGCCTTGAATGTTCCACGCACTCGGATAGAACGTATTGTAGCAGAAAATAGTCCGGTAACTCCTGATACAG
CACTACGATTAGCCTATTTTTTTGATACAACAGCTGAATTCTGGCTTAACATGCAAGCTGCTTACGACGTTAGTGTCTTA
CAAGCTGAAAAAGCAGATGAATTTTCCAAAATTAGTAAATTTGAATGTAGGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|