Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 258846..259432 Replicon chromosome
Accession NZ_CP056852
Organism Citrobacter freundii strain RHBSTW-00119

Toxin (Protein)


Gene name doc Uniprot ID A0A0J1QS94
Locus tag HV078_RS01230 Protein ID WP_032937237.1
Coordinates 259064..259432 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0J1N092
Locus tag HV078_RS01225 Protein ID WP_032937236.1
Coordinates 258846..259067 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV078_RS01200 254645..255571 + 927 WP_003023435.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HV078_RS01205 255568..256845 + 1278 WP_032950432.1 branched chain amino acid ABC transporter permease LivM -
HV078_RS01210 256842..257609 + 768 WP_003023438.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HV078_RS01215 257627..258340 + 714 WP_003827581.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HV078_RS01220 258443..258724 + 282 WP_003023442.1 hypothetical protein -
HV078_RS01225 258846..259067 + 222 WP_032937236.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV078_RS01230 259064..259432 + 369 WP_032937237.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HV078_RS01235 259676..260992 + 1317 WP_003837839.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HV078_RS01240 261093..261980 + 888 WP_032950430.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HV078_RS01245 261977..262822 + 846 WP_003023450.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HV078_RS01250 262825..263895 + 1071 WP_032950429.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 255568..264635 9067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13617.91 Da        Isoelectric Point: 6.9891

>T164330 WP_032937237.1 NZ_CP056852:259064-259432 [Citrobacter freundii]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIVLSANPDFVAMTVEAAAGQLTLEQIAHRLRH

Download         Length: 369 bp

>T164330 NZ_CP072897:1562954-1563277 [Bartonella henselae]
ATGCGTGGATCTCTCGTCACAATAGCTATGCAAGGCGATTTTGGTAAACCAAGACCTGCGTTAATCATTCAAGCCAATCA
ATTTAGTGAACATACAAGTGTAACGGTTTTACCCATTACTAGCACACTTGTTGCAGCGCCATTACTTCGCATTACGATTC
AGCCAAACGCTAAAAATGGTTTGCAAAAACCTTCGCAAGTCATGATTGATAAGATTATGACGGTAAGATGTGAAAAAGTT
AGTCCAGCTTTCGGCTCCATTCATGCAGATAAAATGGTAGAAATTGAACGCTGTTTAGCTGTATTTTTAGGAATAGTAAA
ATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8306.41 Da        Isoelectric Point: 4.7906

>AT164330 WP_032937236.1 NZ_CP056852:258846-259067 [Citrobacter freundii]
MRTMNYSEARQNLAEVLESAVTGVPVTITRRGHKPAVIISAEEFERYQAARLDDEFADIMMIHGNEIRELADK

Download         Length: 222 bp

>AT164330 NZ_CP072897:1562730-1562954 [Bartonella henselae]
ATGGCTACAATGCACGTCAATGAGCGCGTTCAAAAACATCGCAATGCACAAAGAAAAGCAGGTTTGCGCTTAATGCAAAT
TTGGGTACCAGATACTCGTCAACCAAACTTTGCAGAAGAGTGTCGCCGCCAATGTCGCTTAGTCGCAAAAATGGATAAAA
CAGATACATCTATGCAGTTGTTAATGGATCAATCTTTAATGGATGTTGATGGCTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1QS94

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1N092

References