Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2640663..2641432 Replicon chromosome
Accession NZ_CP056850
Organism Citrobacter freundii strain RHBSTW-00120

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV079_RS12895 Protein ID WP_181625347.1
Coordinates 2640663..2641145 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV079_RS12900 Protein ID WP_168246960.1
Coordinates 2641136..2641432 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV079_RS12865 2635787..2636578 - 792 WP_181636772.1 carboxymuconolactone decarboxylase family protein -
HV079_RS12870 2636603..2636826 - 224 Protein_2524 hypothetical protein -
HV079_RS12875 2636851..2637900 - 1050 WP_181636773.1 NAD(P)-dependent alcohol dehydrogenase -
HV079_RS12880 2638351..2638635 + 285 Protein_2526 aldo/keto reductase -
HV079_RS12885 2638670..2639563 - 894 WP_137363300.1 LysR family transcriptional regulator -
HV079_RS12890 2639711..2640517 + 807 WP_181636774.1 SDR family oxidoreductase -
HV079_RS12895 2640663..2641145 - 483 WP_181625347.1 GNAT family N-acetyltransferase Toxin
HV079_RS12900 2641136..2641432 - 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HV079_RS12905 2641545..2643527 - 1983 WP_117342783.1 MBL fold metallo-hydrolase -
HV079_RS12910 2643836..2644465 - 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HV079_RS12915 2644745..2645932 - 1188 WP_174360862.1 outer membrane protein transport protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-148)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17724.35 Da        Isoelectric Point: 8.4768

>T164318 WP_181625347.1 NZ_CP056850:c2641145-2640663 [Citrobacter freundii]
MEINVTAPALLTEGHDLQPFNCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T164318 NZ_CP072894:c2127376-2127035 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTTCACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT164318 WP_168246960.1 NZ_CP056850:c2641432-2641136 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT164318 NZ_CP072894:c2127606-2127376 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References