Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1006496..1007150 Replicon chromosome
Accession NZ_CP056850
Organism Citrobacter freundii strain RHBSTW-00120

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HV079_RS04920 Protein ID WP_096755799.1
Coordinates 1006743..1007150 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HV079_RS04915 Protein ID WP_096755798.1
Coordinates 1006496..1006762 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV079_RS04890 1001704..1003143 - 1440 WP_181637573.1 6-phospho-beta-glucosidase BglA -
HV079_RS04895 1003264..1003992 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HV079_RS04900 1004045..1004356 + 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
HV079_RS04905 1004520..1005179 + 660 WP_096755796.1 hemolysin III family protein -
HV079_RS04910 1005259..1006239 - 981 WP_181517851.1 tRNA-modifying protein YgfZ -
HV079_RS04915 1006496..1006762 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HV079_RS04920 1006743..1007150 + 408 WP_096755799.1 protein YgfX Toxin
HV079_RS04925 1007196..1007717 - 522 WP_096755800.1 flavodoxin FldB -
HV079_RS04930 1007830..1008726 + 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HV079_RS04935 1008750..1009463 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV079_RS04940 1009469..1011202 + 1734 WP_181637574.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T164317 WP_096755799.1 NZ_CP056850:1006743-1007150 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T164317 NZ_CP072894:198880-199146 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT164317 WP_096755798.1 NZ_CP056850:1006496-1006762 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164317 NZ_CP072894:198617-198880 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGATGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References