Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 897682..898485 Replicon chromosome
Accession NZ_CP056850
Organism Citrobacter freundii strain RHBSTW-00120

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7L6TYH6
Locus tag HV079_RS04380 Protein ID WP_047358707.1
Coordinates 897682..898062 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7L6TXP6
Locus tag HV079_RS04385 Protein ID WP_047358708.1
Coordinates 898120..898485 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV079_RS04360 893263..893412 + 150 WP_181624696.1 hypothetical protein -
HV079_RS04365 893930..894697 - 768 WP_146717828.1 hypothetical protein -
HV079_RS04370 896024..896872 - 849 WP_047358705.1 DUF4942 domain-containing protein -
HV079_RS04375 897194..897685 - 492 WP_047358706.1 hypothetical protein -
HV079_RS04380 897682..898062 - 381 WP_047358707.1 TA system toxin CbtA family protein Toxin
HV079_RS04385 898120..898485 - 366 WP_047358708.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV079_RS04390 898507..898728 - 222 WP_047358709.1 DUF987 domain-containing protein -
HV079_RS04395 898742..899221 - 480 WP_047358710.1 DNA repair protein RadC -
HV079_RS04400 899234..899707 - 474 WP_047358733.1 antirestriction protein -
HV079_RS04405 899976..900794 - 819 WP_047358711.1 DUF945 domain-containing protein -
HV079_RS04410 900912..901163 - 252 WP_047358712.1 DUF905 family protein -
HV079_RS04415 901354..901821 - 468 WP_047358713.1 hypothetical protein -
HV079_RS04420 901918..902319 - 402 WP_047358714.1 hypothetical protein -
HV079_RS04425 902525..903412 - 888 WP_047358715.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14216.38 Da        Isoelectric Point: 10.0929

>T164316 WP_047358707.1 NZ_CP056850:c898062-897682 [Citrobacter freundii]
MQTLSAIPTRKAPSHPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

>T164316 NZ_CP072891:c1786652-1786395 [Enterococcus hirae]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13417.25 Da        Isoelectric Point: 6.4780

>AT164316 WP_047358708.1 NZ_CP056850:c898485-898120 [Citrobacter freundii]
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAMYPTPDNSITR

Download         Length: 366 bp

>AT164316 NZ_CP072891:c1786914-1786645 [Enterococcus hirae]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TXP6

References