164310

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1491..2010 Replicon plasmid pRHBSTW-00126_3
Accession NZ_CP056841
Organism Citrobacter freundii strain RHBSTW-00126

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag HV083_RS23895 Protein ID WP_000277490.1
Coordinates 1726..2010 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag HV083_RS23890 Protein ID WP_000124732.1
Coordinates 1491..1733 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV083_RS23890 1491..1733 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HV083_RS23895 1726..2010 + 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV083_RS23900 2148..2240 - 93 Protein_3 DNA partition complex ParG -
HV083_RS23905 2746..3078 - 333 Protein_4 glycogen/starch synthase -
HV083_RS23910 3078..4376 - 1299 WP_053287384.1 glucose-1-phosphate adenylyltransferase -
HV083_RS23915 4391..6367 - 1977 WP_046810948.1 glycogen debranching protein GlgX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..61353 61353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T164310 WP_000277490.1 NZ_CP056841:1726-2010 [Citrobacter freundii]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T164310 NZ_CP072885:40311-40463 [Enterococcus faecium]
ATTGAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATCTCATCATCATCTTTATAAGGATGGTGTTAGAATCACTGT
TCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGAAAAAAATTTTAAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT164310 WP_000124732.1 NZ_CP056841:1491-1733 [Citrobacter freundii]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT164310 NZ_CP072885:40497-40928 [Enterococcus faecium]
ATGTTAAGCGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTTTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGAGCTACTTCCAGAACCAACACCAATCAATAAGATCTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCGAATATTTGAAAGAAACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGTTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References