164308

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4544282..4544948 Replicon chromosome
Accession NZ_CP056839
Organism Citrobacter freundii strain RHBSTW-00126

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HV083_RS21800 Protein ID WP_048220009.1
Coordinates 4544589..4544948 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HV083_RS21795 Protein ID WP_003031625.1
Coordinates 4544282..4544599 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV083_RS21760 4539404..4539898 + 495 WP_003031646.1 mannose/fructose/sorbose PTS transporter subunit IIB -
HV083_RS21765 4539964..4540761 + 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
HV083_RS21770 4540773..4541597 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV083_RS21775 4541665..4542888 + 1224 WP_003031639.1 L-sorbose 1-phosphate reductase -
HV083_RS21780 4542890..4543702 + 813 WP_032948295.1 shikimate 5-dehydrogenase -
HV083_RS21785 4543754..4544086 - 333 WP_048220011.1 hypothetical protein -
HV083_RS21790 4543994..4544272 + 279 WP_008324306.1 putative addiction module antidote protein -
HV083_RS21795 4544282..4544599 - 318 WP_003031625.1 helix-turn-helix domain-containing protein Antitoxin
HV083_RS21800 4544589..4544948 - 360 WP_048220009.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV083_RS21805 4545162..4545851 + 690 WP_003841421.1 dipeptidase PepE -
HV083_RS21810 4545917..4547548 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13491.50 Da        Isoelectric Point: 10.1224

>T164308 WP_048220009.1 NZ_CP056839:c4544948-4544589 [Citrobacter freundii]
MTKPLYWVGHAWKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVAGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T164308 NZ_CP072884:189072-189338 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11522.46 Da        Isoelectric Point: 9.0005

>AT164308 WP_003031625.1 NZ_CP056839:c4544599-4544282 [Citrobacter freundii]
MSHEVEASSGNVYADLGVYDAEQMQLKAQLAMVIGEILQRKGLTQQQSAQLLGMTQPKLSNLLRGQFRGISEVKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT164308 NZ_CP072884:188809-189072 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References