Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3944341..3944995 Replicon chromosome
Accession NZ_CP056839
Organism Citrobacter freundii strain RHBSTW-00126

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HV083_RS18930 Protein ID WP_003026936.1
Coordinates 3944341..3944748 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HV083_RS18935 Protein ID WP_003026938.1
Coordinates 3944729..3944995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV083_RS18910 3940289..3942022 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
HV083_RS18915 3942028..3942741 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV083_RS18920 3942765..3943661 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
HV083_RS18925 3943775..3944296 + 522 WP_003026933.1 flavodoxin FldB -
HV083_RS18930 3944341..3944748 - 408 WP_003026936.1 protein YgfX Toxin
HV083_RS18935 3944729..3944995 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
HV083_RS18940 3945252..3946232 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
HV083_RS18945 3946326..3946985 - 660 WP_003026947.1 hemolysin III family protein -
HV083_RS18950 3947148..3947459 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
HV083_RS18955 3947512..3948240 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HV083_RS18960 3948361..3949794 + 1434 WP_048218552.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T164305 WP_003026936.1 NZ_CP056839:c3944748-3944341 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T164305 NZ_CP072881:471653-471994 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTTCACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT164305 WP_003026938.1 NZ_CP056839:c3944995-3944729 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164305 NZ_CP072881:471423-471653 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References