Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 702240..702816 Replicon chromosome
Accession NZ_CP056839
Organism Citrobacter freundii strain RHBSTW-00126

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag HV083_RS03315 Protein ID WP_003019170.1
Coordinates 702240..702527 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag HV083_RS03320 Protein ID WP_003019167.1
Coordinates 702514..702816 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV083_RS03290 697593..699005 - 1413 WP_048219782.1 PLP-dependent aminotransferase family protein -
HV083_RS03295 699183..699347 + 165 WP_003019180.1 DUF1127 domain-containing protein -
HV083_RS03300 699495..699959 + 465 WP_003019178.1 MarR family transcriptional regulator -
HV083_RS03305 699966..701033 + 1068 WP_032948464.1 HlyD family secretion protein -
HV083_RS03310 701023..702087 + 1065 WP_048219780.1 DUF2955 domain-containing protein -
HV083_RS03315 702240..702527 + 288 WP_003019170.1 BrnT family toxin Toxin
HV083_RS03320 702514..702816 + 303 WP_003019167.1 BrnA antitoxin family protein Antitoxin
HV083_RS03325 702880..703836 - 957 WP_003019163.1 GTPase -
HV083_RS03330 703849..704043 - 195 WP_003830038.1 YbdD/YjiX family protein -
HV083_RS03335 704154..706304 - 2151 WP_048219778.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11157.53 Da        Isoelectric Point: 7.0746

>T164293 WP_003019170.1 NZ_CP056839:702240-702527 [Citrobacter freundii]
MPMEFEWDANKAQSNLRKHGVRFEDAVLVFDDPQHLSRQDRHENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

>T164293 NZ_CP072869:c269506-268637 [Rhizobium sp. NLR16a]
ATGGCTAAAGAAATCAGAAACGTCGGCGCCTCGGTGCGCGCCCGCCTGTTGCAACTCGCCAAGGCAAGCGGGCAAAGCTT
CGATCTCGTCCTGACGCGTTTCGCCCTTGAACGGTTATTGTTCCGGCTTAGCCAGTCGCCCCACGCCGATCGCTTCGTTC
TAAAAGGGGCGATGTTGATGATGAGTTGGTTCGACAATCCGCACCGAGGCACGCGCGACCTGGATCTTTTGGGTTTCGGT
GATCCGAGTCCGGACCCGATGCTTGAGACATTTCGGGAAATTCTGGCGCAAGAGGCCGACGATGGCGTTACGTTCGACGC
TGATACGCTGCATGTGGATCGTATTCGCGAGGCACTGGATTATGGTGGGCTCAGGCTGCGGGTGATCGCTTCGATCAGCG
GAGCCCGGATCAACCTGACCATCGACATCGGTTTTGGCGATGCGCTTGAGCCTGGGGTGGAGGTTTTGGATTATCCTTCC
ATGCTCGATTTTCCGATGCCGCGGCTTCGGGCCTATGCGCGAGAAACGGTCATTGCCGAGAAGTTCCAGGCAATGGTGAT
GCTGGGGCGAGTAAACAGCCGCATGAAGGATTTCTACGACATCTGGATCCTCAGCAGGTCTTTCGACTTCAGCGATGATC
GGCTGGCGCGCGCAATAGCCGCTACCTTTGATCGCCGCGAGACACCGATCCCCATTGACCTGCCGGACGCCCTAACGGAC
GCCTTTGCCAAGGACCAGCAAAAGCAGCGACAATGGCGTGCTTTCATTGAAGGCGTTGCACACAATCCTGGCGATCTGAT
CGACGTCATCGCGCAGATTGCCACATTCCTGATGCCGCACGCGGTTGCGGCTGCGAGGCTGGACGAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11462.06 Da        Isoelectric Point: 10.1293

>AT164293 WP_003019167.1 NZ_CP056839:702514-702816 [Citrobacter freundii]
MSMVKHKRGSVSALSAQHEAELKALANKSDDDIDYSDIPVTEDKQWSEATRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT164293 NZ_CP072869:c270116-269499 [Rhizobium sp. NLR16a]
ATGCCCAGTTCAGTCACGCAACGCCAAATCGCTCGGACCGTGCTAACCGAGCGCGGAATAGCACGTTTCGTCGAACTGCG
GAACGCAGGGGTGACGGCTGCCACCATGAGCCGAATGGAACGAGATGGTGAAGTGCTGCGGCTTGCCCGCGGTCTCTATC
AACTTCCTGATGCGCAGCTCGACGCCAGCCACAGCCTGGCGGAGGTTGCCAAACGCGCGCCCAAAGCCGTTATCTGCCTC
GTTTCGGCATTGGCATTTCACAGCCTGACAGATCAGCTCCCCGGACAAATCTGGCTTGCCATAGGCCGTAAGGACTGGCC
GCCGAAGCTGGAAGCCCCCGCTGTGCGCATCGTGCGCTTCACAGACAGCCTTCTCAACGACAGCGTCGAAACCCATATCA
TTGAAGGCGTTCCTGTGAGGGTCTTTGGAATCGCCAAGACAATTGCCGATTGCTTTCGATATCGCAACAAGATCGGCCTT
TCGGTAGCGATAGAAGGGCTGCAGGAGGCGCTGCGGCAACGAAGGGCTACTCCTGGCGAAATCGCCAACCAGGCCGAACG
CGGTGGCGTTGGCTCTGTGATCCGGCCGTATCTCGAGGCGCTGACCGCCAATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References