Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4369015..4369694 Replicon chromosome
Accession NZ_CP056834
Organism Citrobacter sp. RHBSTW-00127

Toxin (Protein)


Gene name ykfI Uniprot ID A0A7D6Z078
Locus tag HV084_RS21120 Protein ID WP_048215514.1
Coordinates 4369015..4369356 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0F6RHY7
Locus tag HV084_RS21125 Protein ID WP_046495841.1
Coordinates 4369377..4369694 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV084_RS21100 4365366..4367210 + 1845 WP_016154549.1 RNA polymerase sigma factor RpoD -
HV084_RS21105 4367256..4367762 - 507 WP_053388745.1 G/U mismatch-specific DNA glycosylase -
HV084_RS21115 4368066..4368899 - 834 WP_046495848.1 DUF4942 domain-containing protein -
HV084_RS21120 4369015..4369356 - 342 WP_048215514.1 TA system toxin CbtA family protein Toxin
HV084_RS21125 4369377..4369694 - 318 WP_046495841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV084_RS21130 4369713..4369934 - 222 WP_000691995.1 DUF987 domain-containing protein -
HV084_RS21135 4369943..4370419 - 477 WP_046495838.1 RadC family protein -
HV084_RS21140 4370435..4370893 - 459 WP_046495834.1 antirestriction protein -
HV084_RS21145 4370972..4371208 - 237 WP_046495830.1 DUF905 domain-containing protein -
HV084_RS21150 4371286..4371696 - 411 WP_046495825.1 hypothetical protein -
HV084_RS21155 4371785..4372399 - 615 WP_046495819.1 hypothetical protein -
HV084_RS21160 4372396..4373100 - 705 WP_181218195.1 WYL domain-containing protein -
HV084_RS21165 4373301..4374134 - 834 WP_181218197.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13014.97 Da        Isoelectric Point: 10.4182

>T164287 WP_048215514.1 NZ_CP056834:c4369356-4369015 [Citrobacter sp. RHBSTW-00127]
MKPQSAATSRAVKPCLSPVAIWQILLTRLLEQHYGLTLNDTPFRDESVIQEHIDAGITLANAVNFLVEKYELVRIDRRRF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T164287 NZ_CP072859:114652-115032 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11869.49 Da        Isoelectric Point: 6.6245

>AT164287 WP_046495841.1 NZ_CP056834:c4369694-4369377 [Citrobacter sp. RHBSTW-00127]
MSNITWGLQRDITPRLGTRLVQEGNRLHYLADRASITGKFSDAECQKLDETFPHFISQMESMLTSGELNPLHVHCVTLYH
TGFTCEADTLGSCGYVYIAIYPTKR

Download         Length: 318 bp

>AT164287 NZ_CP072859:114431-114652 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6Z078

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6RHY7

References