Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4213730..4214569 Replicon chromosome
Accession NZ_CP056834
Organism Citrobacter sp. RHBSTW-00127

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV084_RS20375 Protein ID WP_094169374.1
Coordinates 4214192..4214569 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV084_RS20370 Protein ID WP_077249796.1
Coordinates 4213730..4214143 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV084_RS20325 4208821..4209708 + 888 WP_000682561.1 50S ribosome-binding GTPase -
HV084_RS20330 4209914..4210315 + 402 WP_000819262.1 hypothetical protein -
HV084_RS20335 4210412..4210879 + 468 WP_000727137.1 hypothetical protein -
HV084_RS20340 4211070..4211320 + 251 Protein_3986 DUF905 family protein -
HV084_RS20345 4211436..4212254 + 819 WP_094169373.1 DUF945 domain-containing protein -
HV084_RS20350 4212254..4212517 + 264 WP_038633754.1 hypothetical protein -
HV084_RS20355 4212595..4212990 + 396 WP_176443286.1 antirestriction protein -
HV084_RS20360 4213043..4213528 + 486 WP_038642868.1 DNA repair protein RadC -
HV084_RS20365 4213540..4213761 + 222 WP_038633763.1 DUF987 domain-containing protein -
HV084_RS20370 4213730..4214143 + 414 WP_077249796.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV084_RS20375 4214192..4214569 + 378 WP_094169374.1 TA system toxin CbtA family protein Toxin
HV084_RS20380 4214566..4215057 + 492 WP_040063379.1 hypothetical protein -
HV084_RS20385 4215087..4215281 + 195 WP_038633777.1 DUF957 domain-containing protein -
HV084_RS20390 4215362..4216210 + 849 WP_040229927.1 DUF4942 domain-containing protein -
HV084_RS20395 4216971..4217297 + 327 Protein_3997 PAAR domain-containing protein -
HV084_RS20400 4217599..4218762 + 1164 WP_094169375.1 S-type pyocin domain-containing protein -
HV084_RS20405 4218759..4219226 + 468 WP_094169376.1 pyocin immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4191105..4254951 63846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(33-132)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14038.90 Da        Isoelectric Point: 6.8604

>T164286 WP_094169374.1 NZ_CP056834:4214192-4214569 [Citrobacter sp. RHBSTW-00127]
MQTQPVSPAREASPRMSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRAVTDITTGKYSKMTR

Download         Length: 378 bp

>T164286 NZ_CP072859:106789-107205 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15178.32 Da        Isoelectric Point: 7.7885

>AT164286 WP_077249796.1 NZ_CP056834:4213730-4214143 [Citrobacter sp. RHBSTW-00127]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS

Download         Length: 414 bp

>AT164286 NZ_CP072859:106562-106792 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References