Detailed information of TA system TA164285

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4061916..4062570
• Replicon: chromosome
• Accession: NZ_CP056834
• Organism: Citrobacter sp. RHBSTW-00127

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HV084_RS19625
• Protein ID: WP_094168630.1
• Coordinates: 4061916..4062323 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: R8WMJ6
• Locus tag: HV084_RS19630
• Protein ID: WP_016154349.1
• Coordinates: 4062304..4062570 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV084_RS19605	4057808..4059541	-	1734	WP_016154344.1	single-stranded-DNA-specific exonuclease RecJ	-
HV084_RS19610	4059547..4060260	-	714	WP_047357820.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV084_RS19615	4060284..4061180	-	897	WP_046274931.1	site-specific tyrosine recombinase XerD	-
HV084_RS19620	4061294..4061815	+	522	WP_016154347.1	flavodoxin FldB	-
HV084_RS19625	4061916..4062323	-	408	WP_094168630.1	protein YgfX	Toxin
HV084_RS19630	4062304..4062570	-	267	WP_016154349.1	FAD assembly factor SdhE	Antitoxin
HV084_RS19635	4062828..4063808	+	981	WP_094168631.1	tRNA-modifying protein YgfZ	-
HV084_RS19640	4063888..4064547	-	660	WP_016154351.1	hemolysin III family protein	-
HV084_RS19645	4064711..4065022	-	312	WP_016154352.1	N(4)-acetylcytidine aminohydrolase	-
HV084_RS19650	4065075..4065803	+	729	WP_008785744.1	MurR/RpiR family transcriptional regulator	-
HV084_RS19655	4065924..4067357	+	1434	WP_094168632.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15864.69 Da
• Isoelectric Point: 11.2845

>T164285 WP_094168630.1 NZ_CP056834:c4062323-4061916 [Citrobacter sp. RHBSTW-00127]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMIKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Nucleotide

• Length: 408 bp

>T164285 NZ_CP072859:c100388-100083 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10557.10 Da
• Isoelectric Point: 5.6375

>AT164285 WP_016154349.1 NZ_CP056834:c4062570-4062304 [Citrobacter sp. RHBSTW-00127]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT164285 NZ_CP072859:c100608-100390 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATACAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: R8WMJ6