Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 3762802..3763534 Replicon chromosome
Accession NZ_CP056834
Organism Citrobacter sp. RHBSTW-00127

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HV084_RS18255 Protein ID WP_094168720.1
Coordinates 3763205..3763534 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A411H489
Locus tag HV084_RS18250 Protein ID WP_015683452.1
Coordinates 3762802..3763167 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV084_RS18205 3758044..3758757 + 714 WP_041692656.1 WYL domain-containing protein -
HV084_RS18210 3758754..3759374 + 621 WP_047414863.1 hypothetical protein -
HV084_RS18215 3759409..3759861 + 453 WP_015683446.1 hypothetical protein -
HV084_RS18220 3759858..3760307 + 450 WP_094168718.1 hypothetical protein -
HV084_RS18225 3760379..3760609 + 231 WP_015683448.1 DUF905 domain-containing protein -
HV084_RS18230 3760708..3761529 + 822 WP_094168719.1 DUF945 domain-containing protein -
HV084_RS18235 3761560..3762003 + 444 WP_047414857.1 antirestriction protein -
HV084_RS18240 3762016..3762558 + 543 WP_041692659.1 DNA repair protein RadC -
HV084_RS18245 3762555..3762776 + 222 WP_015683451.1 DUF987 domain-containing protein -
HV084_RS18250 3762802..3763167 + 366 WP_015683452.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV084_RS18255 3763205..3763534 + 330 WP_094168720.1 TA system toxin CbtA family protein Toxin
HV084_RS18260 3764184..3764444 + 261 WP_047358937.1 helix-turn-helix domain-containing protein -
HV084_RS18265 3764484..3765245 + 762 WP_072058793.1 3-deoxy-D-manno-oct-2-ulosonate III transferase WaaZ -
HV084_RS18270 3765353..3765910 - 558 Protein_3583 tail fiber assembly protein -
HV084_RS18275 3765910..3766695 - 786 Protein_3584 tail fiber protein -
HV084_RS18280 3767190..3767546 + 357 WP_047358939.1 hypothetical protein -
HV084_RS18285 3767868..3768434 + 567 WP_181640787.1 Slp family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3761560..3766695 5135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12601.29 Da        Isoelectric Point: 9.5061

>T164284 WP_094168720.1 NZ_CP056834:3763205-3763534 [Citrobacter sp. RHBSTW-00127]
MQTLSSHPTRATQPYLSPVETWQRLLTHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYELIRIDRKGF
SWQQQTPYISVVDILRARRNTGLLKTNVK

Download         Length: 330 bp

>T164284 NZ_CP072859:c47309-47175 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13477.21 Da        Isoelectric Point: 5.8743

>AT164284 WP_015683452.1 NZ_CP056834:3762802-3763167 [Citrobacter sp. RHBSTW-00127]
MNNHSESGTKPENLTCQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLTSGE
LSPLHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPDQPEPH

Download         Length: 366 bp

>AT164284 NZ_CP072859:47354-47414 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A411H489

References