Detailed information of TA system TA164273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 695505..696032
• Replicon: chromosome
• Accession: NZ_CP056834
• Organism: Citrobacter sp. RHBSTW-00127

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV084_RS03400
• Protein ID: WP_094760972.1
• Coordinates: 695757..696032 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV084_RS03395
• Protein ID: WP_094760973.1
• Coordinates: 695505..695753 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV084_RS03345	690682..690957	+	276	WP_094760982.1	hypothetical protein	-
HV084_RS03350	691063..691296	+	234	WP_094760981.1	DUF905 domain-containing protein	-
HV084_RS03355	691293..691523	+	231	WP_094760980.1	hypothetical protein	-
HV084_RS03360	691640..692458	+	819	WP_094760979.1	DUF945 domain-containing protein	-
HV084_RS03365	692572..692991	+	420	WP_094760978.1	antirestriction protein	-
HV084_RS03370	693003..693512	+	510	WP_171862414.1	DNA repair protein RadC	-
HV084_RS03375	693509..693730	+	222	WP_094760977.1	DUF987 family protein	-
HV084_RS03380	693753..694094	+	342	WP_094760976.1	type IV toxin-antitoxin system YeeU family antitoxin	-
HV084_RS03385	694138..694479	+	342	WP_094760975.1	TA system toxin CbtA family protein	-
HV084_RS03390	694595..695428	+	834	WP_094760974.1	DUF4942 domain-containing protein	-
HV084_RS03395	695505..695753	+	249	WP_094760973.1	ribbon-helix-helix domain-containing protein	Antitoxin
HV084_RS03400	695757..696032	+	276	WP_094760972.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV084_RS03405	696148..696942	+	795	WP_094760971.1	helix-turn-helix transcriptional regulator	-
HV084_RS03410	697071..697943	-	873	WP_181640804.1	HNH endonuclease	-
HV084_RS03415	698202..698651	+	450	WP_094169251.1	hypothetical protein	-
HV084_RS03420	698645..698971	+	327	WP_016151544.1	DUF1493 family protein	-
HV084_RS03425	698990..699475	+	486	WP_016151545.1	type VI secretion system tube protein Hcp	-
HV084_RS03430	699538..699900	-	363	WP_094169250.1	endoribonuclease SymE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	677340..698971	21631

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-42)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10981.34 Da
• Isoelectric Point: 4.8888

>T164273 WP_094760972.1 NZ_CP056834:695757-696032 [Citrobacter sp. RHBSTW-00127]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCAGLAAHPAIGVQQPRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Nucleotide

• Length: 276 bp

>T164273 NZ_CP072858:2043371-2043474 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.33 Da
• Isoelectric Point: 8.8294

>AT164273 WP_094760973.1 NZ_CP056834:695505-695753 [Citrobacter sp. RHBSTW-00127]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA

Nucleotide

• Length: 249 bp

>AT164273 NZ_CP072858:c2043512-2043241 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT