Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 693753..694479 | Replicon | chromosome |
| Accession | NZ_CP056834 | ||
| Organism | Citrobacter sp. RHBSTW-00127 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | HV084_RS03385 | Protein ID | WP_094760975.1 |
| Coordinates | 694138..694479 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | HV084_RS03380 | Protein ID | WP_094760976.1 |
| Coordinates | 693753..694094 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV084_RS03340 | 689551..690408 | + | 858 | WP_094760983.1 | hypothetical protein | - |
| HV084_RS03345 | 690682..690957 | + | 276 | WP_094760982.1 | hypothetical protein | - |
| HV084_RS03350 | 691063..691296 | + | 234 | WP_094760981.1 | DUF905 domain-containing protein | - |
| HV084_RS03355 | 691293..691523 | + | 231 | WP_094760980.1 | hypothetical protein | - |
| HV084_RS03360 | 691640..692458 | + | 819 | WP_094760979.1 | DUF945 domain-containing protein | - |
| HV084_RS03365 | 692572..692991 | + | 420 | WP_094760978.1 | antirestriction protein | - |
| HV084_RS03370 | 693003..693512 | + | 510 | WP_171862414.1 | DNA repair protein RadC | - |
| HV084_RS03375 | 693509..693730 | + | 222 | WP_094760977.1 | DUF987 family protein | - |
| HV084_RS03380 | 693753..694094 | + | 342 | WP_094760976.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HV084_RS03385 | 694138..694479 | + | 342 | WP_094760975.1 | TA system toxin CbtA family protein | Toxin |
| HV084_RS03390 | 694595..695428 | + | 834 | WP_094760974.1 | DUF4942 domain-containing protein | - |
| HV084_RS03395 | 695505..695753 | + | 249 | WP_094760973.1 | ribbon-helix-helix domain-containing protein | - |
| HV084_RS03400 | 695757..696032 | + | 276 | WP_094760972.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HV084_RS03405 | 696148..696942 | + | 795 | WP_094760971.1 | helix-turn-helix transcriptional regulator | - |
| HV084_RS03410 | 697071..697943 | - | 873 | WP_181640804.1 | HNH endonuclease | - |
| HV084_RS03415 | 698202..698651 | + | 450 | WP_094169251.1 | hypothetical protein | - |
| HV084_RS03420 | 698645..698971 | + | 327 | WP_016151544.1 | DUF1493 family protein | - |
| HV084_RS03425 | 698990..699475 | + | 486 | WP_016151545.1 | type VI secretion system tube protein Hcp | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 677340..698971 | 21631 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12990.86 Da Isoelectric Point: 9.7617
>T164272 WP_094760975.1 NZ_CP056834:694138-694479 [Citrobacter sp. RHBSTW-00127]
MQTQYNHPYRATPSQPSPVEIWQKMLTHLLAKHYGLTLNDTPFSEEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
GWQDASPYLRAVDILRARQATGLLRGRRHLAAH
MQTQYNHPYRATPSQPSPVEIWQKMLTHLLAKHYGLTLNDTPFSEEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
GWQDASPYLRAVDILRARQATGLLRGRRHLAAH
Download Length: 342 bp
>T164272 NZ_CP072858:c1809270-1808896 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12705.72 Da Isoelectric Point: 9.7668
>AT164272 WP_094760976.1 NZ_CP056834:693753-694094 [Citrobacter sp. RHBSTW-00127]
MKINKTTSTPVWGLRKDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKQMEAALRTGALNPREAR
RFTTEIRGITCEADTCGSFGYVYLSLYPTIVKS
MKINKTTSTPVWGLRKDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKQMEAALRTGALNPREAR
RFTTEIRGITCEADTCGSFGYVYLSLYPTIVKS
Download Length: 342 bp
>AT164272 NZ_CP072858:c1809727-1809359 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|