Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 47556..48292 Replicon plasmid pRHBSTW-00128_2
Accession NZ_CP056831
Organism Klebsiella pneumoniae strain RHBSTW-00128

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag HV085_RS26175 Protein ID WP_003026803.1
Coordinates 47556..48038 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag HV085_RS26180 Protein ID WP_003026799.1
Coordinates 48026..48292 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV085_RS26160 43193..44155 + 963 WP_004152113.1 M48 family metalloprotease -
HV085_RS26165 44243..45497 + 1255 Protein_41 IS3 family transposase -
HV085_RS26170 45998..47344 - 1347 WP_020314316.1 ISNCY family transposase -
HV085_RS26175 47556..48038 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
HV085_RS26180 48026..48292 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
HV085_RS26185 48468..48722 - 255 WP_004152108.1 hypothetical protein -
HV085_RS26190 48798..49055 - 258 WP_004152107.1 hypothetical protein -
HV085_RS26195 49104..49307 - 204 WP_004152106.1 hemolysin expression modulator Hha -
HV085_RS26200 49341..49709 - 369 WP_004152105.1 hypothetical protein -
HV085_RS26205 49753..50247 - 495 WP_004152104.1 DNA-binding protein -
HV085_RS26210 50278..50853 - 576 WP_004152103.1 hypothetical protein -
HV085_RS26215 50841..51110 - 270 WP_181578707.1 hypothetical protein -
HV085_RS26220 51468..51818 + 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
HV085_RS26225 51868..52230 + 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..152250 152250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T164271 WP_003026803.1 NZ_CP056831:c48038-47556 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T164271 NZ_CP072858:995997-996332 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT164271 WP_003026799.1 NZ_CP056831:c48292-48026 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT164271 NZ_CP072858:995749-995997 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References