164253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4739795..4740461 Replicon chromosome
Accession NZ_CP056809
Organism Citrobacter freundii strain RHBSTW-00162

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HV103_RS22670 Protein ID WP_046671413.1
Coordinates 4740102..4740461 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag HV103_RS22665 Protein ID WP_003844682.1
Coordinates 4739795..4740112 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV103_RS22635 4735469..4736293 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HV103_RS22640 4736361..4737584 + 1224 WP_003031639.1 L-sorbose 1-phosphate reductase -
HV103_RS22645 4737586..4738398 + 813 WP_046671410.1 shikimate 5-dehydrogenase -
HV103_RS22650 4738444..4738800 - 357 WP_046671411.1 hypothetical protein -
HV103_RS22655 4738942..4739103 + 162 WP_003841416.1 phage protein -
HV103_RS22660 4739507..4739785 + 279 WP_046671412.1 putative addiction module antidote protein -
HV103_RS22665 4739795..4740112 - 318 WP_003844682.1 helix-turn-helix domain-containing protein Antitoxin
HV103_RS22670 4740102..4740461 - 360 WP_046671413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV103_RS22675 4740675..4741364 + 690 WP_046671414.1 dipeptidase PepE -
HV103_RS22680 4741430..4743061 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13451.52 Da        Isoelectric Point: 10.2555

>T164253 WP_046671413.1 NZ_CP056809:c4740461-4740102 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAIYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T164253 NZ_CP072850:392298-392600 [Vibrio cholerae MO10]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT164253 WP_003844682.1 NZ_CP056809:c4740112-4739795 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT164253 NZ_CP072850:392053-392310 [Vibrio cholerae MO10]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References