Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 803724..804378 Replicon chromosome
Accession NZ_CP056809
Organism Citrobacter freundii strain RHBSTW-00162

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HV103_RS03925 Protein ID WP_003026936.1
Coordinates 803971..804378 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HV103_RS03920 Protein ID WP_003026938.1
Coordinates 803724..803990 (+) Length 89 a.a.

Genomic Context

HV103_RS03905HV103_RS03910HV103_RS03920HV103_RS03925HV103_RS03935HV103_RS03940HV103_RS03945HV103_RS03895HV103_RS03900HV103_RS03915HV103_RS03930
Location: 801260..801571 (312 bp)
Type: Others
Protein ID: WP_003026949.1
Location: 801734..802393 (660 bp)
Type: Others
Protein ID: WP_046670319.1
Location: 803724..803990 (267 bp)
Type: Antitoxin
Protein ID: WP_003026938.1
Location: 803971..804378 (408 bp)
Type: Toxin
Protein ID: WP_003026936.1
Location: 805058..805954 (897 bp)
Type: Others
Protein ID: WP_003026928.1
Location: 805978..806691 (714 bp)
Type: Others
Protein ID: WP_003825520.1
Location: 806697..808430 (1734 bp)
Type: Others
Protein ID: WP_016150943.1
Location: 798924..800357 (1434 bp)
Type: Others
Protein ID: WP_046670318.1
Location: 800479..801207 (729 bp)
Type: Others
Protein ID: WP_003838265.1
Location: 802487..803467 (981 bp)
Type: Others
Protein ID: WP_003026944.1
Location: 804423..804944 (522 bp)
Type: Others
Protein ID: WP_003026933.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HV103_RS03895798924..800357-1434WP_046670318.16-phospho-beta-glucosidase BglA-
HV103_RS03900800479..801207-729WP_003838265.1MurR/RpiR family transcriptional regulator-
HV103_RS03905801260..801571+312WP_003026949.1N(4)-acetylcytidine aminohydrolase-
HV103_RS03910801734..802393+660WP_046670319.1hemolysin III family protein-
HV103_RS03915802487..803467-981WP_003026944.1tRNA-modifying protein YgfZ-
HV103_RS03920803724..803990+267WP_003026938.1FAD assembly factor SdhEAntitoxin
HV103_RS03925803971..804378+408WP_003026936.1protein YgfXToxin
HV103_RS03930804423..804944-522WP_003026933.1flavodoxin FldB-
HV103_RS03935805058..805954+897WP_003026928.1site-specific tyrosine recombinase XerD-
HV103_RS03940805978..806691+714WP_003825520.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
HV103_RS03945806697..808430+1734WP_016150943.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T164237 WP_003026936.1 NZ_CP056809:803971-804378 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T164237 NZ_CP072848:c433725-433447 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT164237 WP_003026938.1 NZ_CP056809:803724-803990 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164237 NZ_CP072848:c434006-433722 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0J1NHY7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6H3AT26

References