Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/-
Location 491552..492205 Replicon chromosome
Accession NZ_CP056784
Organism Acinetobacter baumannii strain TP1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HWQ22_RS02360 Protein ID WP_000607077.1
Coordinates 491816..492205 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag HWQ22_RS02355 Protein ID WP_001288210.1
Coordinates 491552..491809 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ22_RS02335 487068..488075 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
HWQ22_RS02340 488094..488471 + 378 WP_001216380.1 50S ribosomal protein L17 -
HWQ22_RS02345 488653..490143 + 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
HWQ22_RS02350 490192..491364 - 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
HWQ22_RS02355 491552..491809 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
HWQ22_RS02360 491816..492205 + 390 WP_000607077.1 membrane protein Toxin
HWQ22_RS02365 492975..494060 + 1086 WP_000049106.1 hypothetical protein -
HWQ22_RS02370 494138..494704 + 567 WP_000651538.1 rhombosortase -
HWQ22_RS02375 494892..497087 + 2196 WP_001158906.1 TRAP transporter large permease subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(10-82)


Sequences


Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T164232 WP_000607077.1 NZ_CP056784:491816-492205 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T164232 NZ_CP072848:420653-420940 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT164232 WP_001288210.1 NZ_CP056784:491552-491809 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT164232 NZ_CP072848:420412-420663 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References