Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 79764..80503 Replicon plasmid p1
Accession NZ_CP056782
Organism Enterobacter cloacae strain D41-sc-1712200

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HWQ17_RS23815 Protein ID WP_148422723.1
Coordinates 79764..80249 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HWQ17_RS23820 Protein ID WP_148422724.1
Coordinates 80237..80503 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ17_RS23795 75206..76195 - 990 WP_148422719.1 tyrosine-type recombinase/integrase -
HWQ17_RS23800 76444..77592 + 1149 WP_148422720.1 hypothetical protein -
HWQ17_RS23805 77690..78190 - 501 WP_148422721.1 DUF4411 family protein -
HWQ17_RS23810 78187..79329 - 1143 WP_148422722.1 XRE family transcriptional regulator -
HWQ17_RS23815 79764..80249 - 486 WP_148422723.1 GNAT family N-acetyltransferase Toxin
HWQ17_RS23820 80237..80503 - 267 WP_148422724.1 DUF1778 domain-containing protein Antitoxin
HWQ17_RS23825 80748..82618 - 1871 Protein_69 Tn3 family transposase -
HWQ17_RS23830 82559..82945 + 387 WP_148422725.1 recombinase family protein -
HWQ17_RS23840 83417..84310 + 894 WP_148422726.1 hypothetical protein -
HWQ17_RS23845 84361..85479 + 1119 WP_148422727.1 threonine/serine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87983 87983
- flank IS/Tn - - 80789..82852 2063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(35-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17496.14 Da        Isoelectric Point: 8.7375

>T164230 WP_148422723.1 NZ_CP056782:c80249-79764 [Enterobacter cloacae]
VGCVTAPEPLSSSHQLAEFVSGETVLDDWLKQRGLKNQALGSARTFVVCKTGTKQVAGFYSLATGSVNHVEATGSLRRNM
PDPIPVIILARLAVDVSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKSFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T164230 NZ_CP072848:415361-415693 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10053.48 Da        Isoelectric Point: 4.5127

>AT164230 WP_148422724.1 NZ_CP056782:c80503-80237 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFSDEQHAEFIDMLDAPVLDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT164230 NZ_CP072848:415680-415994 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References