Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-MazE |
Location | 2724811..2725473 | Replicon | chromosome |
Accession | NZ_CP056779 | ||
Organism | Enterobacter cloacae strain D41-sc-1712200 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | HWQ17_RS13040 | Protein ID | WP_176609103.1 |
Coordinates | 2724811..2725209 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | HWQ17_RS13045 | Protein ID | WP_148420397.1 |
Coordinates | 2725213..2725473 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HWQ17_RS13015 | 2720147..2721211 | + | 1065 | WP_148420401.1 | fimbrial protein | - |
HWQ17_RS13020 | 2721231..2721866 | - | 636 | WP_148420482.1 | response regulator transcription factor | - |
HWQ17_RS13025 | 2722440..2723060 | + | 621 | WP_148420400.1 | response regulator transcription factor | - |
HWQ17_RS13030 | 2723134..2723814 | + | 681 | WP_148420399.1 | EAL domain-containing protein | - |
HWQ17_RS13035 | 2723848..2724648 | - | 801 | WP_148420398.1 | lipoprotein NlpA | - |
HWQ17_RS13040 | 2724811..2725209 | - | 399 | WP_176609103.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HWQ17_RS13045 | 2725213..2725473 | - | 261 | WP_148420397.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
HWQ17_RS13050 | 2725653..2726072 | - | 420 | WP_148420396.1 | GNAT family N-acetyltransferase | - |
HWQ17_RS13055 | 2726259..2726828 | + | 570 | WP_148420395.1 | TetR/AcrR family transcriptional regulator | - |
HWQ17_RS13060 | 2726978..2728099 | + | 1122 | WP_148420394.1 | efflux RND transporter periplasmic adaptor subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14729.96 Da Isoelectric Point: 6.4849
>T164216 WP_176609103.1 NZ_CP056779:c2725209-2724811 [Enterobacter cloacae]
MLHMLDTNIVSHLVRQHPEVVNRYSHITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICDWDSAAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQNLTVEDWTVAS
MLHMLDTNIVSHLVRQHPEVVNRYSHITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICDWDSAAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQNLTVEDWTVAS
Download Length: 399 bp
>T164216 NZ_CP072844:1459409-1459699 [Psychrosphaera aestuarii]
ATGAAATTTAATTTATCTAAAAAAGCTAAATTAGATTTAATAAAAATTGCTCGCTACACGCAACTTAATTGGGGCTGGCA
GCAGAGAAATGACTATTTGAAGTTACTTGATAGTGCCTTCCATCAAATTGCAGCAGAGCCTGAACTAGGTTATGCCTGTG
ATTACATTAGAGAAGGCTACAGAAAGCGACCGCAAGGAAGCCATGTAATTTATTACAAAGAATTCGGAAGAGAAGAGGTT
GTAATTATTCGAGTTCTGCATAAAAGCATGGATGTACACCGGGCTATCTGA
ATGAAATTTAATTTATCTAAAAAAGCTAAATTAGATTTAATAAAAATTGCTCGCTACACGCAACTTAATTGGGGCTGGCA
GCAGAGAAATGACTATTTGAAGTTACTTGATAGTGCCTTCCATCAAATTGCAGCAGAGCCTGAACTAGGTTATGCCTGTG
ATTACATTAGAGAAGGCTACAGAAAGCGACCGCAAGGAAGCCATGTAATTTATTACAAAGAATTCGGAAGAGAAGAGGTT
GTAATTATTCGAGTTCTGCATAAAAGCATGGATGTACACCGGGCTATCTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 10066.41 Da Isoelectric Point: 9.6547
>AT164216 WP_148420397.1 NZ_CP056779:c2725473-2725213 [Enterobacter cloacae]
MERTAKLVKKGRNQVVVLPTEFAFETESVYIKRDAEGNVVLTARSEKERHRDNFLRMLKQTHVPDSFLSKEERNQSYTTR
DPLEGL
MERTAKLVKKGRNQVVVLPTEFAFETESVYIKRDAEGNVVLTARSEKERHRDNFLRMLKQTHVPDSFLSKEERNQSYTTR
DPLEGL
Download Length: 261 bp
>AT164216 NZ_CP072844:1459168-1459407 [Psychrosphaera aestuarii]
ATGGCGAAAAATACAAGTGTTACATTAGGTGAACATTTCGATTCATTTATTTCTCAGCAATTAGAGTCTGGTAGGTATGG
GTCTGCAAGTGAAGTTCTAAGGGCTGGTTTACGAGCTTTAGAAGATCAAGAATTGAAAATGAACAATTTAAGAAATATGT
TGGTTGAAGGAGAAAATAGCGGAATAGCTGACTATTCATATGACACACTATTAAGTGACTTGGATAAAGAAAATCATTGA
ATGGCGAAAAATACAAGTGTTACATTAGGTGAACATTTCGATTCATTTATTTCTCAGCAATTAGAGTCTGGTAGGTATGG
GTCTGCAAGTGAAGTTCTAAGGGCTGGTTTACGAGCTTTAGAAGATCAAGAATTGAAAATGAACAATTTAAGAAATATGT
TGGTTGAAGGAGAAAATAGCGGAATAGCTGACTATTCATATGACACACTATTAAGTGACTTGGATAAAGAAAATCATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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