Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2724811..2725473 Replicon chromosome
Accession NZ_CP056779
Organism Enterobacter cloacae strain D41-sc-1712200

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HWQ17_RS13040 Protein ID WP_176609103.1
Coordinates 2724811..2725209 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HWQ17_RS13045 Protein ID WP_148420397.1
Coordinates 2725213..2725473 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ17_RS13015 2720147..2721211 + 1065 WP_148420401.1 fimbrial protein -
HWQ17_RS13020 2721231..2721866 - 636 WP_148420482.1 response regulator transcription factor -
HWQ17_RS13025 2722440..2723060 + 621 WP_148420400.1 response regulator transcription factor -
HWQ17_RS13030 2723134..2723814 + 681 WP_148420399.1 EAL domain-containing protein -
HWQ17_RS13035 2723848..2724648 - 801 WP_148420398.1 lipoprotein NlpA -
HWQ17_RS13040 2724811..2725209 - 399 WP_176609103.1 type II toxin-antitoxin system VapC family toxin Toxin
HWQ17_RS13045 2725213..2725473 - 261 WP_148420397.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HWQ17_RS13050 2725653..2726072 - 420 WP_148420396.1 GNAT family N-acetyltransferase -
HWQ17_RS13055 2726259..2726828 + 570 WP_148420395.1 TetR/AcrR family transcriptional regulator -
HWQ17_RS13060 2726978..2728099 + 1122 WP_148420394.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-118)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14729.96 Da        Isoelectric Point: 6.4849

>T164216 WP_176609103.1 NZ_CP056779:c2725209-2724811 [Enterobacter cloacae]
MLHMLDTNIVSHLVRQHPEVVNRYSHITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICDWDSAAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQNLTVEDWTVAS

Download         Length: 399 bp

>T164216 NZ_CP072844:1459409-1459699 [Psychrosphaera aestuarii]
ATGAAATTTAATTTATCTAAAAAAGCTAAATTAGATTTAATAAAAATTGCTCGCTACACGCAACTTAATTGGGGCTGGCA
GCAGAGAAATGACTATTTGAAGTTACTTGATAGTGCCTTCCATCAAATTGCAGCAGAGCCTGAACTAGGTTATGCCTGTG
ATTACATTAGAGAAGGCTACAGAAAGCGACCGCAAGGAAGCCATGTAATTTATTACAAAGAATTCGGAAGAGAAGAGGTT
GTAATTATTCGAGTTCTGCATAAAAGCATGGATGTACACCGGGCTATCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10066.41 Da        Isoelectric Point: 9.6547

>AT164216 WP_148420397.1 NZ_CP056779:c2725473-2725213 [Enterobacter cloacae]
MERTAKLVKKGRNQVVVLPTEFAFETESVYIKRDAEGNVVLTARSEKERHRDNFLRMLKQTHVPDSFLSKEERNQSYTTR
DPLEGL

Download         Length: 261 bp

>AT164216 NZ_CP072844:1459168-1459407 [Psychrosphaera aestuarii]
ATGGCGAAAAATACAAGTGTTACATTAGGTGAACATTTCGATTCATTTATTTCTCAGCAATTAGAGTCTGGTAGGTATGG
GTCTGCAAGTGAAGTTCTAAGGGCTGGTTTACGAGCTTTAGAAGATCAAGAATTGAAAATGAACAATTTAAGAAATATGT
TGGTTGAAGGAGAAAATAGCGGAATAGCTGACTATTCATATGACACACTATTAAGTGACTTGGATAAAGAAAATCATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References