Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 192144..192883 Replicon plasmid p1
Accession NZ_CP056777
Organism Enterobacter cloacae strain DSM 30054

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag HWQ16_RS26950 Protein ID WP_013087172.1
Coordinates 192398..192883 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag HWQ16_RS26945 Protein ID WP_012540086.1
Coordinates 192144..192410 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ16_RS26915 187374..187910 - 537 WP_013087166.1 GNAT family N-acetyltransferase -
HWQ16_RS26920 188035..189786 - 1752 WP_162875198.1 arsenical pump-driving ATPase -
HWQ16_RS26925 189813..190175 - 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -
HWQ16_RS26930 190251..190796 - 546 WP_013087169.1 sigma-70 family RNA polymerase sigma factor -
HWQ16_RS26935 190805..191518 - 714 WP_013087170.1 arsenical resistance protein ArsH -
HWQ16_RS26940 191520..191843 - 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
HWQ16_RS26945 192144..192410 + 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
HWQ16_RS26950 192398..192883 + 486 WP_013087172.1 GNAT family N-acetyltransferase Toxin
HWQ16_RS26955 193302..194642 + 1341 WP_000589001.1 ISNCY family transposase -
HWQ16_RS26960 194898..195320 - 423 WP_032072095.1 nickel resistance OB fold protein NcrY -
HWQ16_RS26965 195482..196612 - 1131 WP_004196366.1 Ni(II)/Co(II) efflux transporter permease subunit NcrC -
HWQ16_RS26970 196625..196894 - 270 WP_004196355.1 nickel-sensing transcriptional repressor NcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..199561 199561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T164211 WP_013087172.1 NZ_CP056777:192398-192883 [Enterobacter cloacae]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T164211 NZ_CP072842:1989726-1989980 [Faecalibacter bovis]
ATGATAATAGCAAGTGTTTCAGATTTCAGAAAAGATATTAAATCTTACTTAGATAGAGTTTCGAAGAATTTTGAAACCTT
AATCATCAACAGAGGGAAAGATTCAGGTATTGTGGTAATGTCATTAGAAGAGTACAATTCTTTAATGGCTACAAATTACG
AATTATCTTCTCGTATCAATGAATCAAGATTAGATGCTGCCATTGAAAAATTAAAAAGTAACCAATCTTTTGAAAGAGAA
TTAATCGAGGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT164211 WP_012540086.1 NZ_CP056777:192144-192410 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT164211 NZ_CP072842:1989981-1990238 [Faecalibacter bovis]
ATGAAATATATTTTCGTAGATGAATCTTGGGAAGATTATTTATTTTGGCAAAAAACCGATAAGAAAAAAGTAAAACGTAT
CAATGATTTATTGAAAGATATTTCACGTACTCCTTTTACTGGTATAGGGAAACCAGAGCCATTAAAACATAAATATTCAG
GGTTTTGGTCACGTAGAATAGATGAAGAACATCGTTTAATTTACAAGTACGAAGACGGTCAGATATTAATAGCAAAGTGC
CGTTTTCATTACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVR5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References