Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 117990..118729 Replicon plasmid p1
Accession NZ_CP056777
Organism Enterobacter cloacae strain DSM 30054

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag HWQ16_RS26500 Protein ID WP_013087269.1
Coordinates 117990..118475 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag HWQ16_RS26505 Protein ID WP_007869691.1
Coordinates 118463..118729 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ16_RS26475 113329..114476 + 1148 WP_139153290.1 IS3 family transposase -
HWQ16_RS26480 114575..115093 + 519 WP_164928071.1 DUF2913 family protein -
HWQ16_RS26485 115227..116057 + 831 WP_100135202.1 hypothetical protein -
HWQ16_RS26495 116805..117623 + 819 WP_013087268.1 abortive infection family protein -
HWQ16_RS26500 117990..118475 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
HWQ16_RS26505 118463..118729 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
HWQ16_RS26510 119382..120395 + 1014 WP_013087098.1 replication initiation protein -
HWQ16_RS26515 121346..122152 + 807 WP_013087100.1 DUF4225 domain-containing protein -
HWQ16_RS26520 122127..122456 - 330 WP_013087101.1 hypothetical protein -
HWQ16_RS26525 122539..122877 - 339 WP_013087102.1 hypothetical protein -
HWQ16_RS26530 122892..123662 - 771 WP_013087103.1 conjugal transfer protein TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..199561 199561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T164210 WP_013087269.1 NZ_CP056777:c118475-117990 [Enterobacter cloacae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T164210 NZ_CP072837:c2041721-2041371 [Macrococcus canis]
ATGAAACGTGGAGATGTTTATTTAGCTGATCTGTCACCAGTGAAGGGGTCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATTGGGAATAAACATAGTCCTACAGTGATTGTAGCCGCAATTACAGCAAAGATTAATAAAGCAAAGA
TCCCCACCCATGTGGAAATTGGCAAGACCACGTATCACCTGGAAAAGGATTCGGTAATATTGCTTGAACAAATTAGAACT
ATTGATAAGAATAGGTTAATTGATCATCTGACAGTGCTTGATAAGGCAAAGATGAAAGAAGTGGATGTGGCACTTTTAAT
TAGTTTAGGGTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT164210 WP_007869691.1 NZ_CP056777:c118729-118463 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT164210 NZ_CP072837:c2041862-2041722 [Macrococcus canis]
ATGAGCCAGAAGCTGGAGCAAATGCTGATTGAAGGATATCAATCAATGGCAGAGATTAATTTATCGATAGCATCAGAACA
TTATATATTAGAATGTGAAGTTAATGATAACCATCAGACATATACCATTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References