Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2683197..2683978 Replicon chromosome
Accession NZ_CP056776
Organism Enterobacter cloacae strain DSM 30054

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5E1AVC8
Locus tag HWQ16_RS12940 Protein ID WP_029882967.1
Coordinates 2683487..2683978 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0M7EE97
Locus tag HWQ16_RS12935 Protein ID WP_013098691.1
Coordinates 2683197..2683490 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ16_RS12920 2680042..2680356 - 315 WP_013098694.1 lipoprotein -
HWQ16_RS12925 2680532..2681164 + 633 WP_013098693.1 response regulator transcription factor -
HWQ16_RS12930 2681161..2682948 + 1788 WP_013098692.1 hybrid sensor histidine kinase/response regulator -
HWQ16_RS12935 2683197..2683490 + 294 WP_013098691.1 DUF1778 domain-containing protein Antitoxin
HWQ16_RS12940 2683487..2683978 + 492 WP_029882967.1 GNAT family N-acetyltransferase Toxin
HWQ16_RS12950 2684416..2685129 - 714 WP_013098689.1 DUF554 domain-containing protein -
HWQ16_RS12955 2685312..2687447 + 2136 WP_013098688.1 ornithine decarboxylase -
HWQ16_RS12960 2687546..2688238 - 693 WP_013098687.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17629.53 Da        Isoelectric Point: 7.2653

>T164198 WP_029882967.1 NZ_CP056776:2683487-2683978 [Enterobacter cloacae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVSGASRTFVCCGNDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLM
ASI

Download         Length: 492 bp

>T164198 NZ_CP072826:3275422-3275790 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 9.8579

>AT164198 WP_013098691.1 NZ_CP056776:2683197-2683490 [Enterobacter cloacae]
MPTANTMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
ATLRKTMQTPAPWEREK

Download         Length: 294 bp

>AT164198 NZ_CP072826:3275204-3275425 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M7EE97

References