164188

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5504505..5505010 Replicon chromosome
Accession NZ_CP056774
Organism Pseudomonas aeruginosa strain CDN129

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HWH78_RS25570 Protein ID WP_003083773.1
Coordinates 5504729..5505010 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HWH78_RS25565 Protein ID WP_003083775.1
Coordinates 5504505..5504732 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWH78_RS25540 5499524..5501017 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
HWH78_RS25545 5501186..5502613 + 1428 WP_003083784.1 GABA permease -
HWH78_RS25550 5502695..5503036 - 342 WP_003101229.1 alkylphosphonate utilization protein -
HWH78_RS25555 5503109..5503609 - 501 WP_003162763.1 LEA type 2 family protein -
HWH78_RS25560 5503710..5504330 + 621 WP_003101226.1 hypothetical protein -
HWH78_RS25565 5504505..5504732 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HWH78_RS25570 5504729..5505010 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HWH78_RS25575 5505310..5506218 + 909 WP_003083769.1 LysR family transcriptional regulator -
HWH78_RS25580 5506250..5506636 - 387 WP_003083767.1 aegerolysin family protein -
HWH78_RS25585 5506840..5507574 - 735 WP_003117208.1 GntR family transcriptional regulator -
HWH78_RS25590 5507675..5508361 - 687 WP_003083762.1 FadR family transcriptional regulator -
HWH78_RS25595 5508410..5509759 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T164188 WP_003083773.1 NZ_CP056774:5504729-5505010 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T164188 NZ_CP072825:5010722-5011009 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT164188 WP_003083775.1 NZ_CP056774:5504505-5504732 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT164188 NZ_CP072825:5010483-5010722 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References