Detailed information of TA system TA164185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3108748..3109264
• Replicon: chromosome
• Accession: NZ_CP056774
• Organism: Pseudomonas aeruginosa strain CDN129

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HWH78_RS14210
• Protein ID: WP_071557699.1
• Coordinates: 3108748..3109029 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A482UCX2
• Locus tag: HWH78_RS14215
• Protein ID: WP_033942931.1
• Coordinates: 3109019..3109264 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWH78_RS14185	3103911..3104129	-	219	WP_071557701.1	AlpA family transcriptional regulator	-
HWH78_RS14190	3104935..3105903	+	969	WP_033942925.1	DUF932 domain-containing protein	-
HWH78_RS14195	3105978..3106982	+	1005	WP_033942926.1	YqaJ viral recombinase family protein	-
HWH78_RS14200	3107075..3107986	+	912	WP_033942927.1	hypothetical protein	-
HWH78_RS14205	3107997..3108494	+	498	WP_033942928.1	DNA repair protein RadC	-
HWH78_RS14210	3108748..3109029	-	282	WP_071557699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HWH78_RS14215	3109019..3109264	-	246	WP_033942931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HWH78_RS14220	3109434..3109871	+	438	WP_033942934.1	hypothetical protein	-
HWH78_RS14225	3109789..3110247	-	459	Protein_2813	hypothetical protein	-
HWH78_RS14230	3110371..3113538	-	3168	WP_033942936.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3089118..3132253	43135

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10721.55 Da
• Isoelectric Point: 10.6485

>T164185 WP_071557699.1 NZ_CP056774:c3109029-3108748 [Pseudomonas aeruginosa]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLEAPKVQADALRDLPGHYKIKLRTAGYRLVYNVEDDRVVVIVVAVGK
RERSAAYKAAGKR

Nucleotide

• Length: 282 bp

>T164185 NZ_CP072825:c4355147-4353825 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCTGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTTACCGCCTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCACTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8653.98 Da
• Isoelectric Point: 4.1469

>AT164185 WP_033942931.1 NZ_CP056774:c3109264-3109019 [Pseudomonas aeruginosa]
MQSVLADVAVSVSELKKNPTGVMAGAGGMPVAVLNHNRVMGYMVPAELYEQMLDRLDDLDLIDVVNARSGEKGVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT164185 NZ_CP072825:c4355413-4355147 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A482UCX2