Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1884796..1886017 Replicon chromosome
Accession NZ_CP056774
Organism Pseudomonas aeruginosa strain CDN129

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HWH78_RS08990 Protein ID WP_003114949.1
Coordinates 1884796..1885374 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HWH78_RS08995 Protein ID WP_019371885.1
Coordinates 1885463..1886017 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWH78_RS08975 1880073..1881350 + 1278 WP_003102743.1 TolC family protein -
HWH78_RS08980 1881340..1883511 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
HWH78_RS08985 1883501..1884688 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HWH78_RS08990 1884796..1885374 - 579 WP_003114949.1 HD domain-containing protein Toxin
HWH78_RS08995 1885463..1886017 - 555 WP_019371885.1 helix-turn-helix domain-containing protein Antitoxin
HWH78_RS09000 1886175..1888370 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HWH78_RS09005 1888375..1888836 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
HWH78_RS09010 1889167..1889490 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HWH78_RS09015 1889503..1889901 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HWH78_RS09020 1889898..1890449 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T164184 WP_003114949.1 NZ_CP056774:c1885374-1884796 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T164184 NZ_CP072825:c4181521-4181189 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAAAGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20440.60 Da        Isoelectric Point: 8.1590

>AT164184 WP_019371885.1 NZ_CP056774:c1886017-1885463 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLDELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT164184 NZ_CP072825:c4181779-4181522 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References