Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5680861..5681471 Replicon chromosome
Accession NZ_CP056760
Organism Klebsiella grimontii strain RHBSTW-00186

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag HV114_RS26910 Protein ID WP_049086919.1
Coordinates 5680861..5681235 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV114_RS26915 Protein ID WP_077253475.1
Coordinates 5681232..5681471 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV114_RS26895 5678016..5678918 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
HV114_RS26900 5678915..5679550 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
HV114_RS26905 5679894..5680823 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
HV114_RS26910 5680861..5681235 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
HV114_RS26915 5681232..5681471 - 240 WP_077253475.1 ribbon-helix-helix domain-containing protein Antitoxin
HV114_RS26920 5681677..5682594 + 918 WP_024360706.1 alpha/beta hydrolase -
HV114_RS26925 5682612..5683553 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
HV114_RS26930 5683598..5684035 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV114_RS26935 5684032..5684892 - 861 WP_004127107.1 virulence factor BrkB family protein -
HV114_RS26940 5684886..5685485 - 600 WP_024360709.1 glucose-1-phosphatase -
HV114_RS26945 5685615..5686400 - 786 WP_064342034.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T164180 WP_049086919.1 NZ_CP056760:c5681235-5680861 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T164180 NZ_CP056760:c5681235-5680861 [Klebsiella grimontii]
ATGATTAAAGGCCCGGCGCTGTTTGATACTAATATTCTCATCGATTTATTCAGCGGTCGCGTTGAAGCGAAACAGGTTCT
GGAGGCTTATCCGCCACAGAATGCGATTAGCCTCATCACGTGGATGGAAGTAATGGTGGGGGCGAAAAAGTATCATCAGG
AACACCGCACGCGTATTGCACTGAGCGCGTTTAATATTATCGATATTTCACAGGATATTGCTGAACGAAGCGTCAATCTC
AGGAAGGAGTATGGGATGAAGCTGCCGGATGCCATCATACTGGCGACAGCGCAAATACATCGTTATGAACTGGTCACGCG
CAATACCAAAGATTTTTTCGGGATACCCGGAGTGATTACGCCTTATCATTTGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT164180 WP_077253475.1 NZ_CP056760:c5681471-5681232 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT164180 NZ_CP056760:c5681471-5681232 [Klebsiella grimontii]
ATGATGACGGGAACGAATATGGGCAGAATACTACTCGACTTATCGGATGACGTTATTAAACGTCTTGAAGACCTCAAACA
GCAGCGCAATCTTCCTCGAGCGGAACTGTTACGCGAGGCGGTTGAACAGTACCTGGAAAGACAAGCTGACACCACTATTT
CCAATGCGCTGGGGATTTGGCAAGGCTGTGAGGAAGATGGAGTTGAATTCGAAAGGAAACTCCGCGAGGAGTGGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References