Detailed information of TA system TA164178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4605620..4606439
• Replicon: chromosome
• Accession: NZ_CP056760
• Organism: Klebsiella grimontii strain RHBSTW-00186

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: HV114_RS21885
• Protein ID: WP_004132607.1
• Coordinates: 4606182..4606439 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: HV114_RS21880
• Protein ID: WP_004132606.1
• Coordinates: 4605620..4606171 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV114_RS21865	4601010..4602407	+	1398	WP_077265738.1	MFS transporter	-
HV114_RS21870	4602531..4603871	+	1341	WP_049085654.1	carbohydrate porin	-
HV114_RS21875	4603974..4605602	-	1629	WP_064342206.1	SAM-dependent methyltransferase	-
HV114_RS21880	4605620..4606171	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
HV114_RS21885	4606182..4606439	-	258	WP_004132607.1	YjhX family toxin	Toxin
HV114_RS21890	4607023..4608207	+	1185	WP_082237570.1	mannonate dehydratase	-
HV114_RS21895	4608284..4609759	+	1476	WP_064342204.1	fructuronate reductase	-
HV114_RS21900	4609896..4610672	+	777	WP_024359123.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T164178 WP_004132607.1 NZ_CP056760:c4606439-4606182 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T164178 NZ_CP072825:372377-372787 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT164178 WP_004132606.1 NZ_CP056760:c4606171-4605620 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT164178 NZ_CP072825:372130-372396 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA