Detailed information of TA system TA164167

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 940156..940813
• Replicon: chromosome
• Accession: NZ_CP056760
• Organism: Klebsiella grimontii strain RHBSTW-00186

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E1DA00
• Locus tag: HV114_RS04575
• Protein ID: WP_024358614.1
• Coordinates: 940403..940813 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: H3N295
• Locus tag: HV114_RS04570
• Protein ID: WP_004124953.1
• Coordinates: 940156..940422 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV114_RS04555	935408..935833	-	426	WP_024358617.1	PTS sugar transporter subunit IIA	-
HV114_RS04560	935954..938752	-	2799	WP_064343189.1	transcriptional regulator DagR	-
HV114_RS04565	938928..939911	-	984	WP_024358615.1	tRNA-modifying protein YgfZ	-
HV114_RS04570	940156..940422	+	267	WP_004124953.1	FAD assembly factor SdhE	Antitoxin
HV114_RS04575	940403..940813	+	411	WP_024358614.1	protein YgfX	Toxin
HV114_RS04580	940822..941343	-	522	WP_024358613.1	flavodoxin FldB	-
HV114_RS04585	941465..942361	+	897	WP_004124942.1	site-specific tyrosine recombinase XerD	-
HV114_RS04590	942384..943097	+	714	WP_004134425.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV114_RS04595	943103..944836	+	1734	WP_049090244.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16135.97 Da
• Isoelectric Point: 10.9455

>T164167 WP_024358614.1 NZ_CP056760:940403-940813 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWEIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Nucleotide

• Length: 411 bp

>T164167 NZ_CP072802:3688115-3688429 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.88 Da
• Isoelectric Point: 5.1296

>AT164167 WP_004124953.1 NZ_CP056760:940156-940422 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT164167 NZ_CP072802:3688426-3688842 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3H3L9