164165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4683424..4684040 Replicon chromosome
Accession NZ_CP056756
Organism Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV117_RS22475 Protein ID WP_077266491.1
Coordinates 4683424..4683795 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag HV117_RS22480 Protein ID WP_015569912.1
Coordinates 4683798..4684040 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV117_RS22460 4680924..4681826 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
HV117_RS22465 4681823..4682458 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
HV117_RS22470 4682455..4683384 + 930 WP_022652077.1 formate dehydrogenase accessory protein FdhE -
HV117_RS22475 4683424..4683795 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
HV117_RS22480 4683798..4684040 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
HV117_RS22485 4684239..4685159 + 921 WP_047051644.1 alpha/beta hydrolase -
HV117_RS22490 4685168..4686109 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
HV117_RS22495 4686154..4686591 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV117_RS22500 4686588..4687469 - 882 WP_003861949.1 virulence factor BrkB family protein -
HV117_RS22505 4687463..4688062 - 600 WP_032649898.1 glucose-1-phosphatase -
HV117_RS22510 4688181..4688981 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T164165 WP_077266491.1 NZ_CP056756:c4683795-4683424 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T164165 NZ_CP072802:3226897-3227004 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT164165 WP_015569912.1 NZ_CP056756:c4684040-4683798 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT164165 NZ_CP072802:c3226849-3226783 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References