Detailed information of TA system TA164163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3106040..3107823
• Replicon: chromosome
• Accession: NZ_CP056756
• Organism: Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV117_RS15090
• Protein ID: WP_047053382.1
• Coordinates: 3106040..3107389 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV117_RS15095
• Protein ID: WP_047053381.1
• Coordinates: 3107386..3107823 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV117_RS15065	3101863..3102798	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
HV117_RS15070	3102967..3103362	+	396	WP_023295055.1	CidA/LrgA family protein	-
HV117_RS15075	3103359..3104054	+	696	WP_015572322.1	CidB/LrgB family autolysis modulator	-
HV117_RS15080	3104183..3105067	+	885	WP_047053384.1	cytidine deaminase	-
HV117_RS15085	3105195..3105905	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
HV117_RS15090	3106040..3107389	+	1350	WP_047053382.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV117_RS15095	3107386..3107823	+	438	WP_047053381.1	helix-turn-helix domain-containing protein	Antitoxin
HV117_RS15100	3107862..3108872	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
HV117_RS15105	3108888..3110408	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
HV117_RS15110	3110488..3111486	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
HV117_RS15115	3111782..3112804	-	1023	WP_047053378.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-129)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51132.76 Da
• Isoelectric Point: 4.6556

>T164163 WP_047053382.1 NZ_CP056756:3106040-3107389 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T164163 NZ_CP072802:3225931-3226038 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16161.57 Da
• Isoelectric Point: 10.5154

>AT164163 WP_047053381.1 NZ_CP056756:3107386-3107823 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT164163 NZ_CP072802:c3225873-3225817 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT