164150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127628..1128248 Replicon chromosome
Accession NZ_CP056756
Organism Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV117_RS05400 Protein ID WP_015571250.1
Coordinates 1127628..1127846 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV117_RS05405 Protein ID WP_006809850.1
Coordinates 1127874..1128248 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV117_RS05370 1123640..1123900 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV117_RS05375 1123903..1124043 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV117_RS05380 1124040..1124750 - 711 WP_047051118.1 GNAT family N-acetyltransferase -
HV117_RS05385 1124852..1126312 + 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
HV117_RS05390 1126284..1126751 - 468 WP_017383209.1 membrane protein -
HV117_RS05395 1126868..1127419 - 552 WP_017694396.1 maltose O-acetyltransferase -
HV117_RS05400 1127628..1127846 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV117_RS05405 1127874..1128248 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV117_RS05410 1128758..1131904 - 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
HV117_RS05415 1131927..1133120 - 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T164150 WP_015571250.1 NZ_CP056756:c1127846-1127628 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T164150 NZ_CP072801:c3716947-3716693 [Thiothrix litoralis]
ATGAGGATAGTTTTTTCATCCAAAGCGTGGGAAGACTATCTGTACTGGCAGCAAGCCGACAAGAAAATCCTGAAACGCAT
CAATGAGTTGATCAAGGCGATTTCCCGCGAGCCATTTGAGGGTATCGGTAAGCCCGAACCGTTGCGGCATGGCTTGTCCG
GCTATTGGTCACGACGGATCAATGATGAACATCGCTTGGTCTACAAGGTGGAAGGTGAGGATTTACTGATCGCTATGTGC
CGCTACCATTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT164150 WP_006809850.1 NZ_CP056756:c1128248-1127874 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT164150 NZ_CP072801:c3717195-3716944 [Thiothrix litoralis]
ATGAACGCCATCTCCTACACCGCTGTGCGAGCGGAACTCGCCAAAACGATGGATCGGGTCTGCGAAGATCACGAACCCAT
CATCATTACCCGCAACCGCGAACAAGCCGTCGTCATGATTTCGTTGGAAGATTACAAAGCGATGGAAGAAACCGCCTATT
TGTTGCGTAGCCCAGCTAATGCCAGTCGCTTGCTGGAATCCATTGCTGAATTGGGGCGTGGGAATGGGCAAGCGCGAGAG
TTGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References