Detailed information of TA system TA164149

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 995096..995805
• Replicon: chromosome
• Accession: NZ_CP056756
• Organism: Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7D6YAQ1
• Locus tag: HV117_RS04775
• Protein ID: WP_071886833.1
• Coordinates: 995437..995805 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV117_RS04770
• Protein ID: WP_047051179.1
• Coordinates: 995096..995416 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV117_RS04730	990656..991490	+	835	Protein_912	DUF945 domain-containing protein	-
HV117_RS04735	991692..992396	+	705	WP_047051185.1	WYL domain-containing protein	-
HV117_RS04740	992393..993007	+	615	WP_047051184.1	hypothetical protein	-
HV117_RS04745	993096..993506	+	411	WP_047051183.1	hypothetical protein	-
HV117_RS04750	993583..993819	+	237	WP_047051182.1	DUF905 domain-containing protein	-
HV117_RS04755	993899..994357	+	459	WP_047051181.1	antirestriction protein	-
HV117_RS04760	994366..994848	+	483	WP_075211782.1	DNA repair protein RadC	-
HV117_RS04765	994857..995078	+	222	WP_016243789.1	DUF987 domain-containing protein	-
HV117_RS04770	995096..995416	+	321	WP_047051179.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV117_RS04775	995437..995805	+	369	WP_071886833.1	TA system toxin CbtA family protein	Toxin
HV117_RS04780	996151..996897	-	747	WP_047051178.1	class I SAM-dependent methyltransferase	-
HV117_RS04785	996908..997165	-	258	WP_003863178.1	YjhX family toxin	-
HV117_RS04790	997425..999362	-	1938	WP_047051177.1	bifunctional diguanylate cyclase/phosphodiesterase	-
HV117_RS04795	999380..999874	-	495	WP_047051176.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13738.90 Da
• Isoelectric Point: 8.1347

>T164149 WP_071886833.1 NZ_CP056756:995437-995805 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T164149 NZ_CP072801:3343470-3343718 [Thiothrix litoralis]
ATGAGCAAGCTGGAAAAACTGCTGGAAAAGATGGGTAACCACAAAGCCACATGGACATGGCATGAACTCTGCTCACTGTT
GGTAAAACTCGGCTACACCCAAGAAGAGGGTGATGGCTCGCGGGTCAAATTCGACAATGGCAACGCCACCGACCTGATCA
ACCTGCACAAGCCACACCCCGGCAACGAGGTAAAGGCTTACGTCATTCGCCAAGTCCGCGAAAAACTAACCACGGGAGGT
ATGTTATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11901.60 Da
• Isoelectric Point: 7.2633

>AT164149 WP_047051179.1 NZ_CP056756:995096-995416 [Enterobacter hormaechei]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS

Nucleotide

• Length: 321 bp

>AT164149 NZ_CP072801:3343715-3344047 [Thiothrix litoralis]
ATGAAAATGCTGGAACACAAAGGCTACTACGGCAGCATCGAAGCCTCAGTCGAAGATGACATCCTTTTCGGCAAGCTCGA
ATTCATCGCCGCACTGGTCAACTACGAGGGCGAAACTGTCCACGCACTCAAAGCCGCATTTGAAGAAGCGGTTGAGGACT
ACCTGACAACCTGCCAAGCCAAAGGCTACACACCAGAAGTACCCTGCAAAGGCAGCTTCAACGTGCGTGTAGGTCACGAT
CTCCACCTTGCAGCAGCGGTAAAAGCCAAAGAACTCGGCATCAGCCTAAACGACTTCGTGCGCAACGCCATCAGCACCGC
AACACCTGCATAA

Structures

Toxin

• AlphaFold DB: A0A7D6YAQ1