Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PumAB/COG3657-dnstrm_HI1420 |
Location | 305650..306246 | Replicon | chromosome |
Accession | NZ_CP056756 | ||
Organism | Enterobacter hormaechei strain RHBSTW-00198 |
Toxin (Protein)
Gene name | PumA | Uniprot ID | A0A837F9W8 |
Locus tag | HV117_RS01490 | Protein ID | WP_023315213.1 |
Coordinates | 305944..306246 (-) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | A0A837FG03 |
Locus tag | HV117_RS01485 | Protein ID | WP_022650216.1 |
Coordinates | 305650..305937 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV117_RS01480 | 304022..305653 | + | 1632 | WP_003860350.1 | Na/Pi cotransporter family protein | - |
HV117_RS01485 | 305650..305937 | - | 288 | WP_022650216.1 | putative addiction module antidote protein | Antitoxin |
HV117_RS01490 | 305944..306246 | - | 303 | WP_023315213.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HV117_RS01495 | 306444..307316 | + | 873 | WP_022646725.1 | 23S rRNA pseudouridine(2604) synthase RluF | - |
HV117_RS01500 | 307317..307589 | - | 273 | WP_047052050.1 | DUF3811 domain-containing protein | - |
HV117_RS01505 | 307640..308584 | - | 945 | WP_032627014.1 | ketopantoate/pantoate/pantothenate transporter PanS | - |
HV117_RS01510 | 308678..310027 | - | 1350 | WP_045344657.1 | lysine-sensitive aspartokinase 3 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11427.21 Da Isoelectric Point: 10.1042
>T164147 WP_023315213.1 NZ_CP056756:c306246-305944 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE
Download Length: 303 bp
>T164147 NZ_CP072801:c2380725-2380552 [Thiothrix litoralis]
ATGACAAATTATCGCTACCTGCTCGACACCAATATCATTTCCAATCTGTTCCGCGAACCTCAAGGCAACGTTTACCAACA
TTTGCAGCGTGTTGGTGAGAATACGGTTTGTACCAGTATTGTGGTCGCCGCTGAGTTGCGTTTTGGGGCAAAAAACGTAA
TTCCCCGATTCTGA
ATGACAAATTATCGCTACCTGCTCGACACCAATATCATTTCCAATCTGTTCCGCGAACCTCAAGGCAACGTTTACCAACA
TTTGCAGCGTGTTGGTGAGAATACGGTTTGTACCAGTATTGTGGTCGCCGCTGAGTTGCGTTTTGGGGCAAAAAACGTAA
TTCCCCGATTCTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10087.57 Da Isoelectric Point: 5.7807
>AT164147 WP_022650216.1 NZ_CP056756:c305937-305650 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD
Download Length: 288 bp
>AT164147 NZ_CP072801:c2380965-2380729 [Thiothrix litoralis]
ATGCAAGCTGAACGTCACGTCCGCCTGTTTCGTAACGGGCGTAATCAAGCCATCCACATTCCTCGTGAATTTGAATTGGC
AGGGAATGAGGCGATTATTCGCCGTGAAGGTAATCGTTTGATCATCGAAGCCTTGCAACGCCCCTCATTGCTCGCTTTTC
TAGCTGCCTGCGTACCATCAGATGTGGATTTTCCCGACATAGATAATCTACCACCGTTGGATGATGTGGTATTTTAA
ATGCAAGCTGAACGTCACGTCCGCCTGTTTCGTAACGGGCGTAATCAAGCCATCCACATTCCTCGTGAATTTGAATTGGC
AGGGAATGAGGCGATTATTCGCCGTGAAGGTAATCGTTTGATCATCGAAGCCTTGCAACGCCCCTCATTGCTCGCTTTTC
TAGCTGCCTGCGTACCATCAGATGTGGATTTTCCCGACATAGATAATCTACCACCGTTGGATGATGTGGTATTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837F9W8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FG03 |