Detailed information of TA system TA164146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 88907..89563
• Replicon: chromosome
• Accession: NZ_CP056756
• Organism: Enterobacter hormaechei strain RHBSTW-00198

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HV117_RS00480
• Protein ID: WP_080344062.1
• Coordinates: 88907..89299 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HV117_RS00485
• Protein ID: WP_047050676.1
• Coordinates: 89303..89563 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV117_RS00455	84567..85202	-	636	WP_047050682.1	LuxR family transcriptional regulator	-
HV117_RS00460	85773..86393	+	621	WP_047050680.1	response regulator transcription factor	-
HV117_RS00465	86469..87149	+	681	WP_047050679.1	EAL domain-containing protein	-
HV117_RS00470	87183..87983	-	801	WP_047050678.1	lipoprotein NlpA	-
HV117_RS00475	88365..88838	+	474	WP_032674176.1	hypothetical protein	-
HV117_RS00480	88907..89299	-	393	WP_080344062.1	type II toxin-antitoxin system VapC family toxin	Toxin
HV117_RS00485	89303..89563	-	261	WP_047050676.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HV117_RS00490	89681..91180	-	1500	WP_047050674.1	MFS transporter	-
HV117_RS00495	91259..91906	+	648	WP_017383663.1	TetR/AcrR family transcriptional regulator	-
HV117_RS00500	91903..92322	-	420	WP_047050673.1	GNAT family N-acetyltransferase	-
HV117_RS00505	92508..93077	+	570	WP_063863414.1	TetR/AcrR family transcriptional regulator	-
HV117_RS00510	93225..94346	+	1122	WP_047050671.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	78456..89563	11107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14585.78 Da
• Isoelectric Point: 5.8985

>T164146 WP_080344062.1 NZ_CP056756:c89299-88907 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAAIYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Nucleotide

• Length: 393 bp

>T164146 NZ_CP072801:c2275134-2274718 [Thiothrix litoralis]
GTGAGAGTGTTGCTGGATACCTGCGTTTTATCTGAATTACGCAAGCAAGATTGCCCGGCACAAGTAAAGTCAGCGGTAGA
AGTATTGGATGATTTCGATCTTTTTGTCAGTGTGATTACCCTAGGCGAAATTGCCAAAGGTATTGCCTTGCTGGATGAAA
GTAAGCGTAAACGTGCCTTGCGTGATTGGTTGGAAACCCTAGAACAACAGTATGGCGAACGCATTTTACCTGTCGATTTG
GAAACCGTGCGCGTGTGGGGCGACATCACCGCCAAAGCACAACAGGCTGGCAAAATAGTCGCGGTAGCGGATGGCTTGAT
CGCCGCCACCGCGATTCGTTACGGTTTACGGGTCATGACACGCAACGTTGATGATTTCTCGCCGACGGGGGCATTACTGA
TAAATCCTTGGGATTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10084.38 Da
• Isoelectric Point: 9.6899

>AT164146 WP_047050676.1 NZ_CP056756:c89563-89303 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Nucleotide

• Length: 261 bp

>AT164146 NZ_CP072801:c2275376-2275131 [Thiothrix litoralis]
ATGATGCAATGGCGCTTGGCAGATGCTAAAAACAGGTTCAGTGAAGTGGTCAACCGTGCTTTGTGCGAGGGGCCGCAACA
AGTTTCCCGCCGCGATGAGGCGGTAGTCGTGTTGTCATTGGCGGATTATCAACGTTTGACCGGTAAACGTACCAGCTTCA
AACGTTTCTTGTTGGATCATACACCGAGCTTGGAGGGGCTGGACTTATCCCGCGACAAGTCTCCCATGCGTGAGGTAGAG
CTGTGA