Detailed information of TA system TA164140

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3743875..3744584
• Replicon: chromosome
• Accession: NZ_CP056751
• Organism: Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7D6YAQ1
• Locus tag: HV128_RS18185
• Protein ID: WP_071886833.1
• Coordinates: 3743875..3744243 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV128_RS18190
• Protein ID: WP_047051179.1
• Coordinates: 3744264..3744584 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV128_RS18165	3739806..3740300	+	495	WP_047051176.1	oxidoreductase	-
HV128_RS18170	3740318..3742255	+	1938	WP_181522303.1	bifunctional diguanylate cyclase/phosphodiesterase	-
HV128_RS18175	3742515..3742772	+	258	WP_003863178.1	YjhX family toxin	-
HV128_RS18180	3742783..3743529	+	747	WP_047051178.1	class I SAM-dependent methyltransferase	-
HV128_RS18185	3743875..3744243	-	369	WP_071886833.1	TA system toxin CbtA family protein	Toxin
HV128_RS18190	3744264..3744584	-	321	WP_047051179.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV128_RS18195	3744602..3744823	-	222	WP_016243789.1	DUF987 domain-containing protein	-
HV128_RS18200	3744832..3745314	-	483	WP_075211782.1	DNA repair protein RadC	-
HV128_RS18205	3745323..3745781	-	459	WP_047051181.1	antirestriction protein	-
HV128_RS18210	3745861..3746097	-	237	WP_047051182.1	DUF905 domain-containing protein	-
HV128_RS18215	3746174..3746584	-	411	WP_047051183.1	hypothetical protein	-
HV128_RS18220	3746673..3747287	-	615	WP_047051184.1	hypothetical protein	-
HV128_RS18225	3747284..3747988	-	705	WP_047051185.1	WYL domain-containing protein	-
HV128_RS18230	3748190..3749024	-	835	Protein_3567	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13738.90 Da
• Isoelectric Point: 8.1347

>T164140 WP_071886833.1 NZ_CP056751:c3744243-3743875 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T164140 NZ_CP072801:c287593-287222 [Thiothrix litoralis]
GTGATTCTGGTTGATACCTCGGTCTGGATTGATCACCTGCGGGTAAAAGACGAACGTTTAGCCATTCTTTTGAATGAAGT
GCAAGTTTGTATGCACCCAATGGTGTGGGGCGAACTCGCGTGTGGCAACCTGAAAAACCGCCCAACCCTGTTGCGTTTAT
GGCAAGGTCTGCCCGCCATCACCCAAGCCAGCCATGCTGAAACCATGTACTGCTTAGAACAACGTAAACTGATGGGCAAA
GGCATCGGCTATGTGGATTTGCACCTTTTAACCACTGTCCTACTATCACCGGGAACACAGATTTGGACGCGGGACAAGCG
TCTACATAACATTGCCACCGAATTAGGCTGTGGCTGGCAGGAATCACACTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11901.60 Da
• Isoelectric Point: 7.2633

>AT164140 WP_047051179.1 NZ_CP056751:c3744584-3744264 [Enterobacter hormaechei]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS

Nucleotide

• Length: 321 bp

>AT164140 NZ_CP072801:c287793-287590 [Thiothrix litoralis]
ATGCGTACTACATTAAACCTTGATGATGAACTATTACGTCAGGCATTTGAGCTGACAGGCATTGCCGAAAAAGCAGCCCT
GTTGCGTGAAAGCCTGAAAGCCCTGATCGAACGCGAAAGCGCCCGCCGCCTCGCTTTATTGGGAGGTTCCGAACCACAAC
TGGAAGCCCAGCCCCGTCGCCGTTCCACGGAAGAAGCCCTGTGA

Structures

Toxin

• AlphaFold DB: A0A7D6YAQ1