Detailed information of TA system TA164128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 1638987..1640770
• Replicon: chromosome
• Accession: NZ_CP056751
• Organism: Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV128_RS07920
• Protein ID: WP_047053382.1
• Coordinates: 1639421..1640770 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV128_RS07915
• Protein ID: WP_047053381.1
• Coordinates: 1638987..1639424 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV128_RS07895	1634006..1635028	+	1023	WP_047053378.1	HTH-type transcriptional regulator GalS	-
HV128_RS07900	1635324..1636322	+	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
HV128_RS07905	1636402..1637922	+	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
HV128_RS07910	1637938..1638948	+	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
HV128_RS07915	1638987..1639424	-	438	WP_047053381.1	helix-turn-helix domain-containing protein	Antitoxin
HV128_RS07920	1639421..1640770	-	1350	WP_047053382.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV128_RS07925	1640905..1641615	-	711	WP_003859314.1	outer membrane permeability protein SanA	-
HV128_RS07930	1641743..1642627	-	885	WP_047053384.1	cytidine deaminase	-
HV128_RS07935	1642756..1643451	-	696	WP_015572322.1	CidB/LrgB family autolysis modulator	-
HV128_RS07940	1643448..1643843	-	396	WP_023295055.1	CidA/LrgA family protein	-
HV128_RS07945	1644012..1644947	+	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-129)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51132.76 Da
• Isoelectric Point: 4.6556

>T164128 WP_047053382.1 NZ_CP056751:c1640770-1639421 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T164128 NZ_CP072799:c15461-15159 [Thiothrix unzii]
ATGCCATCATTAATTTTTAGCCATACCGCCCTGCTGGATTTAGAGCGGTTACGGGCATTTTTACGCGCCAAGAACCTACC
AGCTGCTCGCCGTGCCGTGGTCAAGATCATGCAGGGGTTGCAGGCACTGGAACAGCACCCGGAGCTAGGCCATACGGTGG
AAGACCGACCGGAAGATTACCGCGAGCTGGTGATTCCCTTCGGCAAAGACGGTTACATTGCCGCCTACCGTTACGCGGGG
GATTCGCTGGTGGTGCTGGGTGTCCGCCATCAACGCGAGTTGCAGCCGCCTACCCTGCCCTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16161.57 Da
• Isoelectric Point: 10.5154

>AT164128 WP_047053381.1 NZ_CP056751:c1639424-1638987 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT164128 NZ_CP072799:c15721-15449 [Thiothrix unzii]
ATGCCAACTTCTATCAAGCTGGACATGGACACCAAAACCCGCCTGCAACGCTTGGCAACCTCGCGCCAGCGTTCCACCCA
TTGGCTGATGCAAGAAGCTATCCGCCAGTATTTGGAGCGTGAGGAACAATTGGCGCAGTTTCGCGACGAAATGCAAACCG
CGTGGGATGACTACCAAGACACCGGCTTACACGTCACCGGCAAAGAAGTGTTTGCTTGGATGGAAACATGGTTCACTGAC
AGCGAAGCCCAGACCCCAAAATGCCATCATTAA