Detailed information of TA system TA164126

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 1420828..1421492
• Replicon: chromosome
• Accession: NZ_CP056751
• Organism: Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: A0A157QTP3
• Locus tag: HV128_RS06890
• Protein ID: WP_007869731.1
• Coordinates: 1420828..1421154 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A0M7FI99
• Locus tag: HV128_RS06895
• Protein ID: WP_007869729.1
• Coordinates: 1421175..1421492 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV128_RS06870	1416327..1417562	+	1236	WP_017383460.1	alanine transaminase	-
HV128_RS06875	1417621..1417692	-	72	WP_099458937.1	membrane protein YpdK	-
HV128_RS06880	1418052..1418972	-	921	WP_086527955.1	kdo(2)-lipid IV(A) palmitoleoyltransferase	-
HV128_RS06885	1419241..1420620	+	1380	WP_047053249.1	diguanylate cyclase	-
HV128_RS06890	1420828..1421154	-	327	WP_007869731.1	TA system toxin CbtA family protein	Toxin
HV128_RS06895	1421175..1421492	-	318	WP_007869729.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV128_RS06900	1421506..1421733	-	228	WP_013098172.1	DUF987 domain-containing protein	-
HV128_RS06905	1421742..1422218	-	477	WP_013098171.1	RadC family protein	-
HV128_RS06910	1422234..1422692	-	459	WP_069729801.1	antirestriction protein	-
HV128_RS06915	1422796..1423035	-	240	WP_007869725.1	DUF905 domain-containing protein	-
HV128_RS06920	1423059..1423880	-	822	WP_039390904.1	DUF945 domain-containing protein	-
HV128_RS06925	1424067..1424267	-	201	WP_069729807.1	permease	-
HV128_RS06930	1424347..1424619	-	273	WP_007869719.1	hypothetical protein	-
HV128_RS06935	1424676..1425413	-	738	WP_069729802.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1414891..1415895	1004

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-106)

Antitoxin

• Antitoxin CbeA (6-104)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12299.25 Da
• Isoelectric Point: 8.9951

>T164126 WP_007869731.1 NZ_CP056751:c1421154-1420828 [Enterobacter hormaechei]
MKTLPATTQRAAKPCLSPVAVWQMLLARLLEQHYGLTINDTPFSDEVVIQQHIDAGITLSDAVNFLVEKYELVRIDRKGF
RWQEQSPYLRAVDILRARQAIGLLRGSH

Nucleotide

• Length: 327 bp

>T164126 NZ_CP072793:3308781-3309197 [Thiothrix unzii]
ATGTATTTGCTTGATACCAATGTCATCAGCGAAATCCGTAAAGGTCAACGCGCTAATTCGGGTGTGCAAGCCTTTTTTCA
ACGAGTCATCAACAACGGTGACAGGTTATGGCTTTCAGCGGTCACTATCGGTGAATTGCGGCGGGGAATTGAGCTGATCC
GTCGTCGTAATGACGCTACACAAGCCCTTCAATTGGAACACTGGTTGGAACAAATTCTGAGCGAGTATCAAGATCATATT
ATCGGGGTTGATGCTGATACTGCTCAATTGTGGGGACGATTGCGTGTCCCACACCACGAACATGAGCTGGATAAACTGAT
CGCTGCCAGCGCGTTACTCTATGATTTAACAGTGGTAACACGCAATGTGGATGATTTTGCAGGAACCGGGGCGAAACTCC
TGAATCCGTTTAGCTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11917.60 Da
• Isoelectric Point: 7.0264

>AT164126 WP_007869729.1 NZ_CP056751:c1421492-1421175 [Enterobacter hormaechei]
MTHIIWGLQRAITPRLGARLVQEGNRLHYLADRASITGMFSDAECRKLDDTFPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT164126 NZ_CP072793:3308558-3308794 [Thiothrix unzii]
ATGTCGAATTTGATCGTCCGTAAACTTGAGCCTGAAATTATCGAGGCACTCAAGCAACGTGCTGCCCGTAACGGCAGAAG
TGCTGAAATGGAACACCGCGCCATTTTGCGAGAGGTGTTGTTGGTGCTGAAAAAACGCAGTCTTGCCGAAATTTTAGCGG
CAATGCCTAACGTTGGCACAGATGCGGATTTTGAACGCATCCAAGGTAAGCAGCAGGTTGCTGATGTATTTGCTTGA

Structures

Toxin

• AlphaFold DB: A0A157QTP3

Antitoxin

• AlphaFold DB: A0A0M7FI99