Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819811..820468 Replicon chromosome
Accession NZ_CP056751
Organism Enterobacter hormaechei strain RHBSTW-00216

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag HV128_RS03935 Protein ID WP_017382887.1
Coordinates 820058..820468 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV128_RS03930 Protein ID WP_003863437.1
Coordinates 819811..820077 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV128_RS03910 815217..816650 - 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -
HV128_RS03915 816767..817498 - 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
HV128_RS03920 817765..818424 + 660 WP_047050804.1 hemolysin III family protein -
HV128_RS03925 818536..819516 - 981 WP_112778520.1 tRNA-modifying protein YgfZ -
HV128_RS03930 819811..820077 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV128_RS03935 820058..820468 + 411 WP_017382887.1 protein YgfX Toxin
HV128_RS03940 820470..820991 - 522 WP_015571793.1 flavodoxin FldB -
HV128_RS03945 821093..821989 + 897 WP_047050805.1 site-specific tyrosine recombinase XerD -
HV128_RS03950 822018..822731 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV128_RS03955 822737..824470 + 1734 WP_047050807.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T164125 WP_017382887.1 NZ_CP056751:820058-820468 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T164125 NZ_CP072793:2216704-2217045 [Thiothrix unzii]
ATGAAGCGAGGGGAAATATGGTGGGCTTCTCTTGAAGAACCCAGAGGCTCAGAACCGGGTTATAAAAGACCCGTTGTCAT
CATCTCATCCGATGCATTCAACCACAGTCGAATACAAACTGTCATTGTCGCAATAGTGACTTCAAATTTACGCTTGGCTA
CTGCTCCGGGTAATATTTCTCTGGCCAAAAGAGACACAGAATTATTAAAAGAATCTGTCATCAATGTTTCACAGATTCTA
ACTATTGATAAATCGTTCTTAATAGAGAAAATCGGCAGATTGCCAGACAAAAAAATATCGGCACTTGATGAAGGCTTAAA
GTTAAGTCTATCTATTTTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT164125 WP_003863437.1 NZ_CP056751:819811-820077 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT164125 NZ_CP072793:2216468-2216704 [Thiothrix unzii]
ATGAAGACAGCCATATCAATACCTGATCCAATATTTCAAGCAGCAGAACTGTTTGCTAATCATTTTGGTATATCCAGAAG
TGAGCTTTACGCCAAAGCTATTGAAGAATACATAGCATCAAGGCGATTTATGAATGTCACCGCAGCATTGAATAAAATCT
ATGGCGATGAACCTTCTGTCTTAGATGATGAATTATATTCAATGCAGATTAAGTCCATTCCACGCGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References