Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4635518..4636114 Replicon chromosome
Accession NZ_CP056747
Organism Enterobacter hormaechei strain RHBSTW-00217

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag HV129_RS21990 Protein ID WP_023315213.1
Coordinates 4635518..4635820 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag HV129_RS21995 Protein ID WP_022650216.1
Coordinates 4635827..4636114 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV129_RS21970 4631737..4633086 + 1350 WP_045344657.1 lysine-sensitive aspartokinase 3 -
HV129_RS21975 4633180..4634124 + 945 WP_032627014.1 ketopantoate/pantoate/pantothenate transporter PanS -
HV129_RS21980 4634175..4634447 + 273 WP_047052050.1 DUF3811 domain-containing protein -
HV129_RS21985 4634448..4635320 - 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
HV129_RS21990 4635518..4635820 + 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV129_RS21995 4635827..4636114 + 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
HV129_RS22000 4636111..4637742 - 1632 WP_003860350.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T164119 WP_023315213.1 NZ_CP056747:4635518-4635820 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T164119 NZ_CP072793:1887352-1887684 [Thiothrix unzii]
ATGAAAGCTGTCTTCGTCGAGTCAACTATTTTTGAAAAGCATCGCTCGGCATACCTGCCAGACGATGAGTTTCAGCAGTT
CCAGAGCGATTTGCTGGAAAATCCGCTGGTGGGTGACGTTATTCAAGGCACTGGAGGTTTGAGGAAGGTACGTGTTGGCA
TCCAAGGTCGGGGAAAACGCGGCGGGGCGCGAGTCATTTATTACTACTACGACAGTTTCCAGCGTTTTTATCTGCTGACC
ATCTATGCCAAAAATGAGATGTCTGACCTGACGGCTGACCAGAAACATCAACTCAAAACATTCATGGAGGTATGGCGTAA
TGAGCAAGCGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT164119 WP_022650216.1 NZ_CP056747:4635827-4636114 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT164119 NZ_CP072793:1887671-1887985 [Thiothrix unzii]
ATGAGCAAGCGTAACTTGTTTGAAGAATTAAGCACAGCCTTGGTGGAAGCTAAGCAACATTCAGAAGGTAAACTCACCTT
GCGCACCCATGTTGTGCAACGCGCAGGTGTGCCTGAAATTAAACCACAGGAAATTTTGACGATTCGGGAAATGTTCAATA
TGTCGCGTGGTGTGTTTGCCCGTCACCTGCATACCTCTGCCCGAACGCTTGAAAGCTGGGAACAAGGACGCACTGCCCCG
AATGGTCAGGCGGTAACGCTATTACGTTTAGTGCAACGGCATCCTGAAACCCTGTCCTACATTGCCGAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References