Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3844061..3844681 Replicon chromosome
Accession NZ_CP056747
Organism Enterobacter hormaechei strain RHBSTW-00217

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV129_RS18235 Protein ID WP_015571250.1
Coordinates 3844463..3844681 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV129_RS18230 Protein ID WP_006809850.1
Coordinates 3844061..3844435 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV129_RS18220 3839189..3840382 + 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV129_RS18225 3840405..3843551 + 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
HV129_RS18230 3844061..3844435 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV129_RS18235 3844463..3844681 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV129_RS18240 3844890..3845441 + 552 WP_017694396.1 maltose O-acetyltransferase -
HV129_RS18245 3845558..3846025 + 468 WP_017383209.1 membrane protein -
HV129_RS18250 3845997..3847457 - 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
HV129_RS18255 3847559..3848269 + 711 WP_047051118.1 GNAT family N-acetyltransferase -
HV129_RS18260 3848266..3848406 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV129_RS18265 3848409..3848669 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T164117 WP_015571250.1 NZ_CP056747:3844463-3844681 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T164117 NZ_CP072793:1004265-1004663 [Thiothrix unzii]
ATGAAGTACCTGCTGGATACCAATATCTGTATTTATCTCATCAAGGAAAAACCGCCAGAAGTGTTGCTGCGCTTCACGGC
ATTGAAACCAGCGCAAGTGTTCATTTCAGCCGTTACGGTGTTTGAATTGTATTATGGCGTTGAAAACAGTCAGGCTCACA
AACGCAACTTGGCGGCGTTGGAAAAATTCCTGCGCCCGATGACTATCCTCGACTTTACCCCTGAAGATGCCAAACAAGCT
GCACGGATTCGTGCCGATCTCAAGCGAAAAGGTACACCCATTGGGGCTTATGATCTGCAAATTGCCGCGACAGCGTTAGC
CAATGGCTTGACGGTAGTGACTAATAACACCGATGAGTTTCAGCGGGTTGTTGGGTTGAGGCTGGAGAATTGGGTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT164117 WP_006809850.1 NZ_CP056747:3844061-3844435 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT164117 NZ_CP072793:1004038-1004265 [Thiothrix unzii]
ATGCAAACAGCAAAAATCTTTCAGAATGGGCGTTCGCAAGCCATTCGTTTACCCAAAGCTTTTCGGCTGTCAGGTACTGA
AGTCAGAATTTCCCGCGAGGGCAATCGCATTATCCTTGAACCGCTAAAGCAATCTTGGGACGATTGGCTGCTCGCCATCG
AACAGTTTTCAGACGATTTCATGGCGCAAGGGCGCGAACAGCCTGCCGTGCAAGAGCGAGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References