Detailed information of TA system TA164106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 1949627..1951410
• Replicon: chromosome
• Accession: NZ_CP056747
• Organism: Enterobacter hormaechei strain RHBSTW-00217

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV129_RS09200
• Protein ID: WP_047053382.1
• Coordinates: 1950061..1951410 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV129_RS09195
• Protein ID: WP_047053381.1
• Coordinates: 1949627..1950064 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV129_RS09175	1944646..1945668	+	1023	WP_047053378.1	HTH-type transcriptional regulator GalS	-
HV129_RS09180	1945964..1946962	+	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
HV129_RS09185	1947042..1948562	+	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
HV129_RS09190	1948578..1949588	+	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
HV129_RS09195	1949627..1950064	-	438	WP_047053381.1	helix-turn-helix domain-containing protein	Antitoxin
HV129_RS09200	1950061..1951410	-	1350	WP_047053382.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV129_RS09205	1951545..1952255	-	711	WP_003859314.1	outer membrane permeability protein SanA	-
HV129_RS09210	1952383..1953267	-	885	WP_047053384.1	cytidine deaminase	-
HV129_RS09215	1953396..1954091	-	696	WP_015572322.1	CidB/LrgB family autolysis modulator	-
HV129_RS09220	1954088..1954483	-	396	WP_023295055.1	CidA/LrgA family protein	-
HV129_RS09225	1954652..1955587	+	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-129)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51132.76 Da
• Isoelectric Point: 4.6556

>T164106 WP_047053382.1 NZ_CP056747:c1951410-1950061 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T164106 NZ_CP072790:3170734-3170997 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16161.57 Da
• Isoelectric Point: 10.5154

>AT164106 WP_047053381.1 NZ_CP056747:c1950064-1949627 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT164106 NZ_CP072790:3170449-3170730 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA