164098

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 28713..29356 Replicon plasmid pRHBSTW-00220_2
Accession NZ_CP056743
Organism Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)


Gene name vagD Uniprot ID A0A155IU92
Locus tag HV132_RS23210 Protein ID WP_000754567.1
Coordinates 28713..29129 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A155IUD1
Locus tag HV132_RS23215 Protein ID WP_023293777.1
Coordinates 29126..29356 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV132_RS23190 25892..26461 - 570 WP_023332907.1 small heat shock protein sHSP20 -
HV132_RS23195 26496..26777 - 282 WP_023332908.1 helix-turn-helix domain-containing protein -
HV132_RS23200 26971..27234 - 264 WP_001295708.1 hypothetical protein -
HV132_RS23205 27394..28362 + 969 WP_016151349.1 IS5 family transposase -
HV132_RS23210 28713..29129 - 417 WP_000754567.1 type II toxin-antitoxin system VapC family toxin Toxin
HV132_RS23215 29126..29356 - 231 WP_023293777.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV132_RS23220 29647..30767 + 1121 WP_085950818.1 IS3-like element ISSen4 family transposase -
HV132_RS23225 31483..32154 + 672 WP_024140048.1 hypothetical protein -
HV132_RS23230 32174..32962 + 789 WP_022631000.1 site-specific integrase -
HV132_RS23235 33020..33277 - 258 WP_000764642.1 hypothetical protein -
HV132_RS23240 33406..33519 - 114 WP_032427600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58103 58103
- inside IScluster/Tn - - 27394..30767 3373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15108.61 Da        Isoelectric Point: 8.5403

>T164098 WP_000754567.1 NZ_CP056743:c29129-28713 [Enterobacter hormaechei]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

>T164098 NZ_CP072790:c2865519-2865124 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.73 Da        Isoelectric Point: 4.4299

>AT164098 WP_023293777.1 NZ_CP056743:c29356-29126 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAQREDVVSDEGRFDP

Download         Length: 231 bp

>AT164098 NZ_CP072790:c2865761-2865516 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155IU92

Antitoxin

Source ID Structure
AlphaFold DB A0A155IUD1

References