Detailed information of TA system TA164092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2384645..2385384
• Replicon: chromosome
• Accession: NZ_CP056742
• Organism: Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: HV132_RS11470
• Protein ID: WP_045329830.1
• Coordinates: 2384899..2385384 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: HV132_RS11465
• Protein ID: WP_047050951.1
• Coordinates: 2384645..2384911 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV132_RS11445	2380121..2381107	+	987	WP_047050955.1	DUF979 domain-containing protein	-
HV132_RS11450	2381117..2382112	+	996	WP_047050954.1	DUF2891 domain-containing protein	-
HV132_RS11455	2382134..2383522	-	1389	WP_047050952.1	MFS transporter	-
HV132_RS11460	2383652..2384581	+	930	WP_047050986.1	LysR family transcriptional regulator	-
HV132_RS11465	2384645..2384911	+	267	WP_047050951.1	DUF1778 domain-containing protein	Antitoxin
HV132_RS11470	2384899..2385384	+	486	WP_045329830.1	GNAT family N-acetyltransferase	Toxin
HV132_RS11475	2385562..2386854	-	1293	WP_047050950.1	glycoside hydrolase	-
HV132_RS11480	2386959..2387717	-	759	WP_015570520.1	DeoR/GlpR family DNA-binding transcription regulator	-
HV132_RS11485	2387804..2388388	+	585	WP_047050949.1	NUDIX domain-containing protein	-
HV132_RS11490	2388473..2389231	+	759	WP_047050948.1	trans-aconitate 2-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17512.18 Da
• Isoelectric Point: 9.9658

>T164092 WP_045329830.1 NZ_CP056742:2384899-2385384 [Enterobacter hormaechei]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T164092 NZ_CP072790:c2365017-2364583 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10089.51 Da
• Isoelectric Point: 4.4857

>AT164092 WP_047050951.1 NZ_CP056742:2384645-2384911 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT164092 NZ_CP072790:c2365278-2365024 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG