Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yafW/CbtA-CbeA
Location 1447127..1447849 Replicon chromosome
Accession NZ_CP056742
Organism Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV132_RS07040 Protein ID WP_142515628.1
Coordinates 1447127..1447447 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag HV132_RS07045 Protein ID WP_142515633.1
Coordinates 1447514..1447849 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV132_RS07030 1445110..1446192 - 1083 WP_069729011.1 DNA-binding transcriptional repressor LacI -
HV132_RS07035 1446429..1446650 - 222 Protein_1361 transposase -
HV132_RS07040 1447127..1447447 - 321 WP_142515628.1 TA system toxin CbtA family protein Toxin
HV132_RS07045 1447514..1447849 - 336 WP_142515633.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV132_RS07050 1447864..1448343 - 480 WP_142515627.1 DNA repair protein RadC -
HV132_RS07055 1448355..1448804 - 450 WP_142515626.1 antirestriction protein -
HV132_RS07060 1448904..1449143 - 240 WP_142515625.1 DUF905 domain-containing protein -
HV132_RS07065 1449220..1449687 - 468 WP_142515624.1 hypothetical protein -
HV132_RS07070 1449711..1450154 - 444 WP_142515623.1 hypothetical protein -
HV132_RS07075 1450154..1450390 - 237 WP_042015432.1 hypothetical protein -
HV132_RS07080 1450431..1451130 - 700 Protein_1370 WYL domain-containing protein -
HV132_RS07085 1451357..1452184 - 828 WP_142515622.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1422234..1473533 51299
- flank IS/Tn - - 1446360..1446650 290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12006.59 Da        Isoelectric Point: 5.9558

>T164083 WP_142515628.1 NZ_CP056742:c1447447-1447127 [Enterobacter hormaechei]
MQISTVPATVPASSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELVRIDRKGF
SWQEQTPFLTATDIHRAKRATGLMST

Download         Length: 321 bp

>T164083 NZ_CP072790:1974681-1974929 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12709.51 Da        Isoelectric Point: 6.7486

>AT164083 WP_142515633.1 NZ_CP056742:c1447849-1447514 [Enterobacter hormaechei]
MNKDTTQIWGLKREITPCFGSRMVQEGHRLHFLADRAGFTGSFSEMQVRHLDEAFPHFVAHLELMLLSGELNPRYAHSVT
LYRNELTCEADTLGSYGYVYIAIYPSNLVKV

Download         Length: 336 bp

>AT164083 NZ_CP072790:1974469-1974681 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References