Detailed information of TA system TA164076

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 47808..48475
• Replicon: chromosome
• Accession: NZ_CP056742
• Organism: Enterobacter hormaechei strain RHBSTW-00220

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV132_RS00255
• Protein ID: WP_059443702.1
• Coordinates: 48155..48475 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV132_RS00250
• Protein ID: WP_059443453.1
• Coordinates: 47808..48134 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV132_RS00220	43007..44386	-	1380	WP_015570106.1	carbohydrate porin	-
HV132_RS00225	44523..44825	-	303	WP_014168006.1	PTS lactose/cellobiose transporter subunit IIA	-
HV132_RS00230	44831..45031	-	201	Protein_45	glycoside hydrolase family 1 protein	-
HV132_RS00235	45104..46224	+	1121	WP_085950818.1	IS3-like element ISSen4 family transposase	-
HV132_RS00240	46435..47256	+	822	WP_015703839.1	DUF945 domain-containing protein	-
HV132_RS00245	47325..47795	+	471	WP_015703840.1	DNA repair protein RadC	-
HV132_RS00250	47808..48134	+	327	WP_059443453.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV132_RS00255	48155..48475	+	321	WP_059443702.1	TA system toxin CbtA family protein	Toxin
HV132_RS00260	48770..50326	+	1557	WP_047050722.1	hypothetical protein	-
HV132_RS00265	50366..50542	-	177	WP_071962261.1	toxin-antitoxin system HicB family antitoxin	-
HV132_RS00270	50679..51020	+	342	WP_006812446.1	SymE family type I addiction module toxin	-
HV132_RS00275	51123..51375	+	253	Protein_54	DNA-binding protein	-
HV132_RS00280	51648..51998	+	351	WP_181522317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HV132_RS00285	51995..52294	+	300	WP_045335986.1	XRE family transcriptional regulator	-
HV132_RS00290	52359..53240	-	882	WP_047050719.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	45104..66662	21558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-99)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12048.92 Da
• Isoelectric Point: 6.2120

>T164076 WP_059443702.1 NZ_CP056742:48155-48475 [Enterobacter hormaechei]
MNTQPATTPQAAKPCLSPLAVWKMLLTILLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAINFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVARL

Nucleotide

• Length: 321 bp

>T164076 NZ_CP072790:1390668-1391099 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12277.99 Da
• Isoelectric Point: 6.3620

>AT164076 WP_059443453.1 NZ_CP056742:47808-48134 [Enterobacter hormaechei]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRASLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 327 bp

>AT164076 NZ_CP072790:1390411-1390671 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA