Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 88032..88558 | Replicon | plasmid pRHBSTW-00309_2 |
| Accession | NZ_CP056738 | ||
| Organism | Enterobacter roggenkampii strain RHBSTW-00309 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HV150_RS25130 | Protein ID | WP_000323025.1 |
| Coordinates | 88032..88319 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HV150_RS25135 | Protein ID | WP_000534858.1 |
| Coordinates | 88319..88558 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV150_RS25090 | 83332..83625 | - | 294 | WP_045620738.1 | hypothetical protein | - |
| HV150_RS25095 | 84314..84642 | - | 329 | Protein_91 | hypothetical protein | - |
| HV150_RS25100 | 84684..85475 | - | 792 | WP_181544260.1 | N-6 DNA methylase | - |
| HV150_RS25105 | 85516..85716 | - | 201 | WP_181544262.1 | hypothetical protein | - |
| HV150_RS25110 | 85804..86265 | - | 462 | WP_053070171.1 | hypothetical protein | - |
| HV150_RS25115 | 86343..86549 | - | 207 | WP_045337189.1 | hypothetical protein | - |
| HV150_RS25120 | 86611..86925 | - | 315 | WP_045337198.1 | hypothetical protein | - |
| HV150_RS25125 | 87802..87960 | - | 159 | WP_008325141.1 | type I toxin-antitoxin system Hok family toxin | - |
| HV150_RS25130 | 88032..88319 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HV150_RS25135 | 88319..88558 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HV150_RS25140 | 88821..89744 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| HV150_RS25145 | 89944..90516 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| HV150_RS25150 | 91159..91824 | - | 666 | Protein_102 | transposase | - |
| HV150_RS25155 | 91972..92952 | - | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
| HV150_RS25160 | 93022..93195 | - | 174 | Protein_104 | helix-turn-helix domain-containing protein | - |
| HV150_RS25165 | 93229..93330 | - | 102 | WP_159106190.1 | DUF5431 family protein | - |
| - | 93316..93440 | - | 125 | NuclAT_0 | - | - |
| - | 93316..93440 | - | 125 | NuclAT_0 | - | - |
| - | 93316..93440 | - | 125 | NuclAT_0 | - | - |
| - | 93316..93440 | - | 125 | NuclAT_0 | - | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..149353 | 149353 | |
| - | flank | IS/Tn | - | - | 91972..92952 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T164075 WP_000323025.1 NZ_CP056738:c88319-88032 [Enterobacter roggenkampii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T164075 NZ_CP072790:1246029-1246403 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT164075 WP_000534858.1 NZ_CP056738:c88558-88319 [Enterobacter roggenkampii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT164075 NZ_CP072790:1245835-1246032 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|