Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4058619..4059276 Replicon chromosome
Accession NZ_CP056737
Organism Enterobacter roggenkampii strain RHBSTW-00309

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HV150_RS19525 Protein ID WP_021242050.1
Coordinates 4058619..4059029 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag HV150_RS19530 Protein ID WP_006178375.1
Coordinates 4059010..4059276 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV150_RS19505 4054612..4056345 - 1734 WP_045351724.1 single-stranded-DNA-specific exonuclease RecJ -
HV150_RS19510 4056351..4057064 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV150_RS19515 4057093..4057989 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
HV150_RS19520 4058091..4058612 + 522 WP_023309099.1 flavodoxin FldB -
HV150_RS19525 4058619..4059029 - 411 WP_021242050.1 protein YgfX Toxin
HV150_RS19530 4059010..4059276 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
HV150_RS19535 4059571..4060551 + 981 WP_008499712.1 tRNA-modifying protein YgfZ -
HV150_RS19540 4060636..4061295 - 660 WP_021242052.1 hemolysin III family protein -
HV150_RS19545 4061561..4062292 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
HV150_RS19550 4062409..4063842 + 1434 WP_106105482.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T164072 WP_021242050.1 NZ_CP056737:c4059029-4058619 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T164072 NZ_CP072790:1019958-1020392 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT164072 WP_006178375.1 NZ_CP056737:c4059276-4059010 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164072 NZ_CP072790:1019773-1019952 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References