Detailed information of TA system TA164071

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 3506753..3507417
• Replicon: chromosome
• Accession: NZ_CP056737
• Organism: Enterobacter roggenkampii strain RHBSTW-00309

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HV150_RS16955
• Protein ID: WP_181543944.1
• Coordinates: 3507091..3507417 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8H9RPW5
• Locus tag: HV150_RS16950
• Protein ID: WP_001548170.1
• Coordinates: 3506753..3507070 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV150_RS16910	3502834..3503571	+	738	WP_044593432.1	DeoR family transcriptional regulator	-
HV150_RS16915	3503628..3503900	+	273	WP_181543940.1	hypothetical protein	-
HV150_RS16920	3503980..3504240	+	261	WP_058691045.1	hypothetical protein	-
HV150_RS16925	3504367..3505188	+	822	WP_181543942.1	DUF945 domain-containing protein	-
HV150_RS16930	3505212..3505451	+	240	WP_007869725.1	DUF905 domain-containing protein	-
HV150_RS16935	3505553..3506011	+	459	WP_032655093.1	antirestriction protein	-
HV150_RS16940	3506027..3506503	+	477	WP_058673375.1	RadC family protein	-
HV150_RS16945	3506512..3506733	+	222	WP_016239820.1	DUF987 domain-containing protein	-
HV150_RS16950	3506753..3507070	+	318	WP_001548170.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV150_RS16955	3507091..3507417	+	327	WP_181543944.1	TA system toxin CbtA family protein	Toxin
HV150_RS16960	3507652..3508989	-	1338	WP_032663131.1	type VI secretion system ImpA and VasL domain-containing protein	-
HV150_RS16965	3509036..3510280	-	1245	WP_106105611.1	GIY-YIG nuclease family protein	-
HV150_RS16970	3510877..3511347	-	471	WP_032663128.1	hypothetical protein	-
HV150_RS16975	3511362..3511814	-	453	WP_106105610.1	type VI secretion system baseplate subunit TssE	-
HV150_RS16980	3511875..3512174	-	300	WP_050488730.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3461388..3514229	52841

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-106)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12368.41 Da
• Isoelectric Point: 9.9972

>T164071 WP_181543944.1 NZ_CP056737:3507091-3507417 [Enterobacter roggenkampii]
MKTLPATTQRAAKPCLAPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
RWQEQSPYLRAVDILRARQAIGLLRGSH

Nucleotide

• Length: 327 bp

>T164071 NZ_CP072790:846320-846748 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11883.46 Da
• Isoelectric Point: 7.0810

>AT164071 WP_001548170.1 NZ_CP056737:3506753-3507070 [Enterobacter roggenkampii]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRHMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Nucleotide

• Length: 318 bp

>AT164071 NZ_CP072790:846039-846296 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA